Table 1 Comparison of existing DCE-MRI packages*

dcemriS4

R

Linux, Windows, Mac OS

BSD

- Standard Kelty- Single-compartment model- Extended Kety

- Non-linear least squares- Bayesian estimation

- motion correction and co-registration - B1 mapping - T1 mapping - AIF fitting - DWI fitting - Pixel processing - Job report for later retreival - Access to R functions

- DICOM - NIFTI - Raw data

http://dcemri.sourceforge.net

dcetool

C, Plugin for ClearCanvas

Windows

Proprietary

- Tofts - Adiabatic tissue homogeniety - Thorwarth- Extended Tofts - Semi-quantitative metrics (Slope/AUC)

Proprietary

- DICOM - Raw data

http://thedcetool.com/

PMI

IDL

Windows

GNU GPL

- Uptake models - Steady-state - Patlak - Model-free deconvolution - Tofts- Extended Tofts - 2CXM - 2C filtration model for kidney - Dual-inlet models for Liver - Semi-quantitative metrics (Slope/Signal enhancement)

- Non-linear Least squares - Truncated singular value decomposition

- ROI and pixel processing - AIF/time series visualization/editing - Access to IDL functions

- DICOM - Raw data

https://sites.google.com/site/plaresmedima/

UMMPerfusion

C, OsiriX plugin

Mac OS

BSD

- Model free deconvolution

- Truncated singular value decomposition

- ROI and pixel processing - Job report for later retreival - AIF/time series visualization/editing

- DICOM

http://ikrsrv1.medma.uni-heidelberg.de/redmine/projects/ummperfusion

Pydcemri

Python

Linux, Windows, Mac OS

GNU GPL

- Tofts - Extended Tofts

- Non-linear Least squares

- Access to python functions

- Raw data

https://github.com/welcheb/pydcemri

DCEMRI.jl

Julia

Linux, Windows, Mac OS

MIT

- Tofts - Extended Tofts - Plasma only

- Non-linear Least squares

- ROI and pixel processing - T1 mapping - Batch processing - Access to Julia functions

- Matlab data

https://github.com/davidssmith/DCEMRI.jl

DCE@UrLAB

IDL

Windows

BSD

- Tofts - Hoffmann - Larsson - Fast exchange limit reference region

- Non-linear Least squares

- ROI and pixel processing - Access to IDL functions

- DICOM - Bruker - Raw data

http://www2.die.upm.es/im/archives/DCEurLAB/

DATforDCEMRI

R

Creative Commons

- Tofts - Semi-quantitative metrics (AUC, MRT - mean residence time)

- Numerical deconvolution

- Pixel processing - Access to R functions

- R readable data formats

https://github.com/cran/DATforDCEMRI

TOPPCAT

Javascript, ImageJ plugin

Linux, Windows, Mac OS

BSD

- Patlak

- Non-linear Least squares

- T1 mapping - Access to ImageJ functions

- ImageJ readable data formats

https://dblab.duhs.duke.edu/modules/dblabs_topcat/

Jim

Java

Linux, Windows, Mac OS

Proprietary

- Tofts - Extended Tofts - One compartment - Fermi - 2CXM - Semi-quantitative metrics (AUC)

Proprietary

- ROI and pixel processing

- DICOM - Analyze - Bruker - Commercial formats - Raw data

http://www.xinapse.com/Manual/index.html

PermGUI

Matlab

Windows

Creative Commons

- Patlak

- T1 mapping - ROI and pixel processing

- DICOM - Analyze - NIFTI

http://www.quantilyze.com/permgui/

BioMap

IDL

Linux, Windows, Mac OS

Proprietary

- Extended Tofts

- Non-linear Least squares

- T1 fitting

- DICOM - Analyze - TIF/PNG

http://www.maldi-msi.org/

ROCKETSHIP

Matlab

Linux, Windows, Mac OS

GNU GPL

- Tofts - Extended Tofts - Fast exchange regime (FXR) - 2CXM - Tissue uptake - Nested-model selection - Patlak - Semi-quantitative metrics (AUC)

- Non-linear Least squares

- T1 mapping - ROI and pixel processing - AIF fitting/import - DWI fitting - Job report for later retreival - AIF/time series visualization/editing - Batch processing - Access to Matlab functions - Model fit comparisons with statistical metrics - Drift correction

- DICOM - Analyze - NIFTI - Raw data - Matlab data

https://github.com/petmri/ROCKETSHIP