Fig. 2

DCE-MRI processing module GUI. GUI modules reflect the schematic outlined in Fig. 2. The “root” DCE module is shown on the left, which launches each sub-module in the pipeline. a defines the sub-module that converts raw image data to concentration time curves. The data are passed to the next sub-module, which allows temporal truncation of the dynamic data and fitting or importing of the AIF (b). DCE-MRI maps are derived using the next sub-module (c). Models can be generated in real time, or the user input can be saved as a data structure job to be run in batch later. Options are provided to perform voxel-by-voxel fits as well as defined ROIs. Raw data curves can be fitted as is, or after being passed through a time smoothing filter. Finally, goodness-of-fit analysis of the fits can be performed with the final sub-module (d)