Combining radiomics with thyroid imaging reporting and data system to predict lateral cervical lymph node metastases in medullary thyroid cancer

Table 3 Quantitative indexes comparisons of TI-RADS model (TM), Radiomics model (RM) and radiomics combined with TI-RADS model (RTM) in 5-fold cross-validation independent test dataset

Model	AUC	ACC	SEN	SPE	PPV	NPV	MCC	F1
TM
fold 1	0.64	0.56	0.67	0.45	0.54	0.59	0.12	0.6
fold 2	0.66	0.58	0.8	0.39	0.53	0.69	0.21	0.64
fold 3	0.77	0.67	0.86	0.5	0.62	0.79	0.38	0.72
fold 4	0.66	0.56	0.71	0.41	0.54	0.6	0.13	0.61
fold 5	0.66	0.57	0.75	0.36	0.56	0.57	0.12	0.64
Average	0.68	0.59	0.76	0.42	0.56	0.65	0.19	0.64
RM
fold 1	0.76	0.67	0.62	0.73	0.68	0.67	0.35	0.65
fold 2	0.72	0.67	0.6	0.74	0.67	0.68	0.34	0.63
fold 3	0.85	0.7	0.76	0.64	0.67	0.74	0.4	0.71
fold 4	0.85	0.74	0.81	0.68	0.71	0.79	0.49	0.76
fold 5	0.73	0.65	0.67	0.64	0.67	0.64	0.3	0.67
Average	0.78	0.69	0.69	0.69	0.68	0.7	0.38	0.68
RTM
fold 1	0.82	0.77	0.71	0.82	0.79	0.75	0.54	0.75
fold 2	0.8	0.7	0.65	0.74	0.68	0.71	0.39	0.66
fold 3	0.9	0.81	0.9	0.73	0.76	0.89	0.64	0.82
fold 4	0.83	0.79	0.71	0.86	0.83	0.76	0.59	0.77
fold 5	0.75	0.65	0.67	0.64	0.67	0.64	0.3	0.67
Average	0.82	0.74	0.73	0.76	0.75	0.75	0.49	0.73
Significance level of Delong test results for different models
Test dataset	TM & RM			TM & RTM		RM & RTM
All (5-fold)	0.030			<0.001		0.077

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