Table 2 Final selected radiomics features and the significant differences of the medullary thyroid carcinoma patients between lateral cervical lymph node metastases (LCLNM) negative and LCLNM positive. Data are presented as medians with ranges in parentheses

First order statistics

 wavelet-HL_firstorder_Median

4.2e-2 (-7.1e-2~0.3)

3.1e-2 (-8.5 e-2~0.1)

<0.001

 wavelet-HL_firstorder_Skewness

-2.7e-2 (-14.3~14.4)

0.2 (-10.9~24.1)

0.017

Shape-based features

 original_shape2D_MinorAxisLength

145.9 (42.4~550.0)

220.3 (53.1~555.4)

<0.001

GLCM

 wavelet-LL_glcm_Imc2

0.98 (0.91~1)

0.98 (0.89~1)

0.042

 wavelet-HH_glcm_ClusterProminence

0.5 (0.5~47.4)

0.6 (0.5~19.1)

0.005

 wavelet-LL_glcm_ClusterShade

142.8 (-68.4~1303.6)

103.7 (-213.2~1018.4)

0.029

GLSZM

 original_glszm_SizeZoneNonUniformity

20.5 (1.9~122.5)

40.7 (3.6~440.9)

<0.001

 wavelet-LH_glszm_ZoneEntropy

5.8 (4.3~6.6)

6.0 (4.4~6.6)

<0.001

 original_glszm_SmallAreaLowGrayLevelEmphasis

2.8e-02 (0.3e-2~0.1)

3.6e-2 (0.6e-2~0.1)

0.010

 waveletLL_glszm_SizeZoneNonUniformity

95.8 (9.8~533.5)

136.8 (9.0~1134.7)

<0.001

NGTDM

 wavelet-HH_ngtdm_Strength

7.5e-4 (3.1e-5~0.1)

2.1e-3 (1.9e-5~4.4e-2)

0.001

GLDM

 wavelet-HH_gldm_LargeDependenceLowGrayLevelEmphasis

4.6 (0.2~18.6)

2.2 (0.2~19.1)

<0.001