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Table 4 Diagnostic performance of T1 mapping- and DKI-derived parameters

From: T1 mapping as a quantitative imaging biomarker for diagnosing cervical cancer: a comparison with diffusion kurtosis imaging

Category

Threshold

AUC (95%CI)

p-value

Sensitivity

Specificity

CSCC vs. CAC

     

 Native T1 (ms)

2002.9

0.772 (0.698–0.835)

< 0.001*

84.4%

71.2%

 T1diff (ms)

1203.0

0.558 (0.447–0.637)

0.288

53.1%

66.4%

 MK

0.94

0.731 (0.655–0.799)

< 0.001*

88.2%

58.4%

 MD (×10− 3 mm2/s)

0.97

0.627 (0.546–0.703)

0.027*

78.1%

48.0%

 ADC (×10− 3 mm2/s)

0.76

0.715 (0.638–0.784)

< 0.001*

75.0%

60.8%

 Combined

 

0.850(0.784–0.901)

< 0.001*

81.25%

84.0%

CSCC grade: high vs. low

     

 Native T1 (ms)

2157.5

0.592 (0.500–0.679)

0.071

85.0%

38.8%

 T1diff (ms)

1267.3

0.762 (0.677–0.833)

< 0.001*

80.0%

70.6%

 MK

1.09

0.721 (0.634–0.797)

< 0.001*

67.5%

80.0%

 MD (×10− 3 mm2/s)

0.90

0.640 (0.549–0.724)

0.012*

45.0%

83.5%

 ADC (×10− 3 mm2/s)

0.64

0.689 (0.600-0.768)

0.001*

47.5%

91.8%

 Combined

 

0.796(0.714–0.862)

0.001*

77.5%

69.4%

CAC grade: high vs. low

     

 Native T1 (ms)

1810.8

0.635 (0.447–0.797)

0.204

50.0%

83.3%

 T1diff (ms)

1224.4

0.766 (0.583–0.897)

0.003*

85.7%

66.7%

 MK

0.82

0.835 (0.662–0.942)

< 0.001*

85.7%

77.8%

 MD (×10− 3 mm2/s)

1.08

0.635 (0.447–0.797)

0.195

71.4%

61.1%

 ADC (×10− 3 mm2/s)

0.85

0.694 (0.507–0.844)

0.060

85.7%

55.6%

 Combined

 

0.893(0.732–0.974)

 

92.86%

77.78%

Stage: advanced vs. early

     

 Native T1 (ms)

2028.7

0.641 (0.561–0.716)

0.002*

70.0%

58.8%

 T1diff (ms)

1142.1

0.582 (0.501–0.660)

0.076

81.7%

40.2%

 MK

0.86

0.507 (0.426–0.587)

0.893

60.0%

30.9%

 MD (×10− 3 mm2/s)

0.82

0.502 (0.422–0.583)

0.958

5.0%

86.6%

 ADC (×10− 3 mm2/s)

0.88

0.512 (0.431–0.593)

0.803

16.7%

92.8%

  1. DKI, diffusion kurtosis imaging; AUC, area under the curve; CSCC, cervical squamous cell carcinoma; CAC, cervical adenocarcinoma; MK, kurtosis along the axial direction; MD, mean diffusivity; ADC, apparent diffusion coefficient
  2. *p < 0.05