Table 3 Univariate and multivariate analyses of OS for patients with ECC. p < 0.05 were considered as statistically significant in univariate or multivariate analysis
Characteristics | Univariable analysis | Multivariable analysis | |||
|---|---|---|---|---|---|
HR (95% CI) | p value | Adjusted HR (95% CI) | p value | ||
Clinicopathological | Gender (female) | 1.83 (1.11–3.00) | 0.017 | 2.27 (1.30–3.94) | 0.004 |
ALT (> 68.4 U/L) | 1.90 (1.11–3.25) | 0.020 | 1.88 (1.02–3.45) | 0.043 | |
TBIL (> 122.5 µmol/L) | 3.01 (1.68–5.37) | < 0.001 |  |  | |
DBIL (> 93.9 µmol/L) | 3.51 (1.87–6.59) | < 0.001 | 4.23 (2.20–8.13) | < 0.001 | |
GGT (> 600.2 U/L) | 0.58 (0.34–0.98) | 0.044 | 0.53 (0.29–0.97) | 0.039 | |
CA199 (> 197.0 U/mL) | 1.88 (1.13–3.13) | 0.015 |  |  | |
Imaging | Tumor size (> 3.2 cm) | 2.19 (1.23–3.88) | 0.008 | 2.53 (1.40–4.60) | 0.002 |
Lesion’s location (dCCA) | 0.64 (0.39–1.05) | 0.077 | 0.49 (0.28–0.85) | 0.011 | |
Morphology (intraductal growth type) | 0.75 (0.43–1.03) | 0.330 |  |  | |
Morphology (mass-forming type) | 1.95 (1.03–3.68) | 0.039 |  |  | |
SIRLiver/Muscle (> 0.7) | 0.45 (0.23–0.87) | 0.018 | 0.41 (0.20–0.83) | 0.014 | |
SIRSpleen/Muscle (> 1.9) | 0.49 (0.30–0.81) | 0.005 | 0.51 (0.29–0.88) | 0.016 | |