Differentiation of multiple brain metastases and glioblastoma with multiple foci using MRI criteria

BMC Medical Imaging

Table 3 Results (p-values) of Tukey’s test of four groups (multiple BM, multifocal mGBM, multicentric mGBM and the mixed mGBM group) for FLAIR and ADC ratios

Parameter	ANOVA model Pr (> F)	Multifocal mGBM vs multicentric mGBM	Multifocal mGBM vs mixed mGBM	Mixed mGBM vs. multicentric mGBM	Multifocal mGBM vs multiple BM	Multiple BM vs multicentric mGBM	Multiple BM vs mixed mGBM
ADC-ratio (tumor)	0.246	0.855	0.482	0.992	0.999	0.763	0.248
ADC-ratio (edema 5 mm)	0.00001	0.991	0.778	0.727	0.005	0.160	0.00001
ADC-ratio (edema 10 mm)	0.216	0.973	0.979	0.998	0.625	0.597	0.319
ADC-ratio (edema 20 mm)	0.873	0.985	0.980	0.999	0.998	0.949	0.896
FLAIR-ratio (tumor)	0.00001	0.993	0.225	0.272	0.0001	0.001	0.009
FLAIR-ratio (edema 5 mm)	0.061	0.121	0.786	0.382	0.999	0.054	0.629
FLAIR-ratio (edema 10 mm)	0.055	0.377	0.960	0.619	0.706	0.075	0.384
FLAIR-ratio (edema 20 mm)	0.078	0.371	0.719	0.839	0.982	0.134	0.270

mGBM Glioblastoma with multiple foci at presentation, BM Brain metastases, ADC Apparent diffusion coefficient, FLAIR Fluid attenuated inversion recovery, edemas were measured in 5, 10 and 20 mm distance (if available) from the contrast enhancing tumor. Bold – differs significantly p < .05

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