Strain ultrasonic elastography imaging features of locally advanced breast cancer: association with response to neoadjuvant chemotherapy and recurrence-free survival

Table 2 Univariable and multivariable analyses of pCR in relation to SE parameters after one and two cycles of NAC

Characteristic	pCR	Non-pCR	Univariable Analysis		Multivariable Analysis
Characteristic	pCR	Non-pCR	Odds Ratio	P value	Odds Ratio	P value
After one cycle of NAC
ES₁	3.63 ± 0.67	4.10 ± 0.69	2.707 (1.512, 4.845)	0.001
SR₁	6.72 ± 3.29	8.98 ± 3.69	1.209 (1.076, 1.360)	0.001	1.236 (1.093, 1.397)	0.001
HP₁	95.33 ± 5.94	97.67 ± 3.73	1.126 (1.020, 1.243)	0.019
AR₁	106.53 ± 8.40	107.20 ± 8.75	1.009 (0.967, 1.053)	0.67
△SR₁	0.41 ± 0.20	0.29 ± 0.19	0.041 (0.006, 0.296)	0.002
△HP₁	0.04 ± 0.04	0.02 ± 0.04	0 (0, 0.153)	0.021
△AR₁	0.05 ± 0.07	0.04 ± 0.07	0.437 (0.003, 73.341)	0.751
Diameter₁	27.12 ± 11.10	32.57 ± 13.93	1.036 (1.004, 1.070)	0.028
△Diameter₁	0.30 ± 0.14	0.26 ± 0.14	0.17 (0.013, 2.309)	0.183
After two cycles of NAC
ES₂	2.98 ± 0.60	3.77 ± 0.74	5.652 (2.769, 11.540)	<0.001
SR₂	3.67 ± 1.89	6.85 ± 2.71	1.867 (1.475, 2.361)	<0.001	1.502 (1.147, 1.967)	0.003
HP₂	86.86 ± 9.86	95.85 ± 6.64	1.16 (1.088, 1.236)	<0.001
AR₂	100.56 ± 4.79	104.41 ± 13.63	1.041 (0.992, 1.093)	0.101
△SR₂	0.67 ± 0.14	0.44 ± 0.20	0.001 (0, 0.009)	<0.001	0.013 (0, 0.429)	0.015
△HP₂	0.12 ± 0.09	0.04 ± 0.07	0 (0, 0)	<0.001
△AR₂	0.11 ± 0.17	0.07 ± 0.13	0.1 (0.006, 1.745)	0.115
Diameter₂	20.0 ± 9.78	26.82 ± 12.69	1.06 (1.019, 1.103)	0.004
△Diameter₂	0.48 ± 0.20	0.40 ± 0.15	0.06 (0.006, 0.577)	0.015

Data are means ± standard deviations. pCR Pathologic complete response, NAC Neoadjuvant chemotherapy, ES Elasticity score, SR Strain ratio, HP Hardness percentage, AR Area ratio. The relative changes in diameter and SE parameters after one and two cycles of NAC were describe as ΔA₁ and ΔA₂, and were calculated by the formula: ΔA = ([value before NAC-value after NAC] / value before NAC) × 100%

ISSN: 1471-2342