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Table 3 Logistic regression analysis of features for diagnosing HCC

From: Threshold growth has a limited role in differentiating hepatocellular carcinoma from other focal hepatic lesions

 

HCC (n = 250)

Non-HCC (n = 176)

Univariable analysis

Multivariable analysis

OR

p value

OR

p value

Major features

 APHE

220 (88.0)

95 (54.0)

6.25 (3.86–10.14)

< 0.001

3.12 (1.71–5.70)

< 0.001

 Washout

193 (77.2)

31 (17.6)

14.73 (9.08–23.92)

< 0.001

10.74 (6.30-18.28)

< 0.001

 Enhancing capsule

117 (46.8)

17 (9.7)

8.23 (4.71–14.38)

< 0.001

7.13 (3.74–13.61)

< 0.001

 Threshold growtha

32 (12.8)

22 (12.5)

1.03 (0.58–1.84)

0.927

  

Ancillary features

 Subthreshold growthb

37 (14.8)

15 (8.5)

1.87 (0.99–3.51)

0.054

  

 Corona enhancement

17 (6.8)

12 (6.8)

0.99 (0.46–2.14)

0.994

  

 Fat sparing in solid mass

4 (1.6)

2 (1.1)

1.42 (0.26–7.81)

0.691

  

 Restricted diffusion

229 (91.6)

147 (83.5)

2.15 (1.18–3.91)

0.012

  

 Mild-moderate T2 hyperintensity

232 (92.8)

143 (8.1)

3.62 (1.90–6.89)

< 0.001

  

 Iron sparing in solid mass

0 (0)

0 (0)

-

-

  

 TP hypointensity

222 (88.8)

122 (69.3)

3.51 (2.11–5.83)

< 0.001

  

 HBP hypointensity

236 (94.4)

142 (80.7)

4.04 (2.10–7.78)

< 0.001

  

 No-nenhancing capsule

8 (3.2)

3 (1.7)

1.91 (0.50–7.29)

0.346

  

 Nodule-in-nodule

15 (6.0)

1 (0.5)

11.17 (1.46–85.36)

0.02

9.83 (1.22–79.27)

0.032

 Mosaic architecture

12 (4.8)

3 (1.7)

2.91 (0.81–10.46)

0.102

  

 Fat-in-mass, more than adjacent liver

19 (7.6)

5 (2.8)

2.81 (1.03–7.68)

0.044

  

 Blood products in mass

18 (7.2)

3 (1.7)

4.48(1.30-15.43)

0.018

  
  1. Data (HCC and non-HCC columns) are the number of observations with the percentage in parentheses. Data in parentheses (OR columns) are 95% confidence intervals. aData refer to 65 HCCs and 69 non-HCC lesions that were examined by EOB-MRI, CE-MRI or CECT within the previous 6 months for which threshold growth could be measured; bData refer to 62 HCCs and 30 non-HCC lesions that were examined by EOB-MRI, CE-MRI or CECT within the previous 1 or 2 years for which the subthreshold growth could be measured. HCC Hepatocellular carcinoma, OR Odds ratio, APHE Arterial-phase hyperenhancement, TP Transitional phase, HBP Hepatobiliary phase