Table 1 Clinical characteristics of patients in training and validation set (n = 1209)
Variable | Training set | Validation set | |||||||
|---|---|---|---|---|---|---|---|---|---|
Moderate pneumonia | Severe pneumonia | P | Moderate pneumonia | Severe pneumonia | P | P | |||
Age (yr,mean ± SD ) | 57.251 ± 13.660 | 63.121 ± 12.390 | 0.000 | 58.396 ± 12.299 | 65.667 ± 12.195 | 0.000 | 0.011 | ||
Sex n(%) | 0.476 | 0.069 | 0.238 | ||||||
^ | |||||||||
Men | 270(50.2%) | 226(52.7%) | 64(47.8%) | 65(60.2%) | |||||
women | 268(49.8%) | 203(47.3%) | 70(52.2%) | 43(39.8%) | |||||
IL-6 | 3.164 ± 4.940 | 16.792 ± 100.663 | 0.000 | 2.613 ± 2.513 | 7.180 ± 16.006 | 0.000 | 0.003 | ||
WBC(109/L) | 5.966 ± 1.886 | 6.384 ± 2.476 | 0.000 | 5.647 ± 1.941 | 6.572 ± 2.609 | 0.003 | 0.243 | ||
L(109/L) | 1.646 ± 0.601 | 1.423 ± 0.680 | 0.000 | 1.434 ± 0.520 | 1.150 ± 0.568 | 0.000 | 0.000 | ||
N(109/L) | 3.703 ± 1.638 | 4.320 ± 2.388 | 0.000 | 3.617 ± 1.781 | 4.852 ± 2.564 | 0.000 | 0.323 | ||
HB(g/L) | 125.507 ± 17.062 | 117.773 ± 23.603 | 0.000 | 122.284 ± 14.681 | 117.082 ± 23.804 | 0.096 | 0.021 | ||
RBC(1012/L) | 4.066 ± 0.547 | 3.869 ± 0.605 | 0.000 | 3.948 ± 0.497 | 3.876 ± 0.559 | 0.208 | 0.043 | ||
PLT(109/L) | 231.213 ± 72.781 | 231.301 ± 85.677 | 0.727 | 265.530 ± 88.988 | 232.269 ± 78.348 | 0.012 | 0.001 | ||
CRP(µg/L) | 3.211 ± 3.393 | 5.002 ± 4.483 | 0.000 | 5.008 ± 3.962 | 7.478 ± 3.727 | 0.000 | 0.000 | ||
PCT(µg/L) | 1.877 ± 2.647 | 1.498 ± 2.434 | 0.003 | 1.396 ± 2.420 | 1.242 ± 2.247 | 0.020 | 0.051 | ||
PT(s) | 11.778 ± 2.825 | 12.596 ± 4.826 | 0.000 | 12.236 ± 2.154 | 12.547 ± 3.287 | 0.042 | 0.100 | ||
TT(s) | 13.549 ± 3.623 | 14.692 ± 5.088 | 0.000 | 14.974 ± 3.236 | 15.086 ± 3.892 | 0.071 | 0.000 | ||
FIB (g/L) | 3.408 ± 1.095 | 3.398 ± 0.941 | 0.097 | 3.373 ± 0.925 | 3.768 ± 1.010 | 0.000 | 0.002 | ||
DD (mg/L) | 1.256 ± 1.937 | 1.720 ± 2.516 | 0.000 | 1.479 ± 2.038 | 3.249 ± 4.969 | 0.000 | 0.000 | ||
BS (mmol/L) | 5.487 ± 2.123 | 6.031 ± 2.747 | 0.000 | 5.295 ± 1.660 | 6.053 ± 2.656 | 0.005 | 0.880 | ||
ALT (u/L) | 32.599 ± 35.669 | 33.361 ± 35.745 | 0.563 | 30.765 ± 23.527 | 37.676 ± 30.337 | 0.087 | 0.039 | ||
AST (u/L) | 22.623 ± 13.871 | 25.920 ± 19.039 | 0.008 | 24.469 ± 17.138 | 33.966 ± 45.357 | 0.009 | 0.007 | ||
TP (g/L) | 65.851 ± 7.689 | 63.932 ± 8.994 | 0.000 | 62.295 ± 8.667 | 61.614 ± 6.204 | 0.059 | 0.000 | ||
ALB (g/L) | 38.369 ± 4.747 | 36.289 ± 5.404 | 0.000 | 35.805 ± 5.214 | 33.883 ± 3.949 | 0.000 | 0.000 | ||
TBil (µmol/L) | 10.544 ± 6.458 | 10.597 ± 5.935 | 0.881 | 9.417 ± 4.131 | 12.193 ± 7.718 | 0.000 | 0.718 | ||
D-Bil (µmol/L) | 3.734 ± 3.974 | 4.063 ± 3.767 | 0.028 | 3.494 ± 1.945 | 5.095 ± 4.819 | 0.000 | 0.083 | ||
BUN (mmol/L) | 4.672 ± 1.493 | 5.168 ± 2.408 | 0.006 | 4.471 ± 3.139 | 4.881 ± 2.415 | 0.143 | 0.000 | ||
Cre (µmol/L) | 66.616 ± 17.565 | 68.839 ± 27.524 | 0.938 | 71.733 ± 54.602 | 70.131 ± 23.705 | 0.578 | 0.913 | ||
BNP (pg/ml) | 14.952 ± 63.098 | 40.715 ± 116.651 | 0.000 | 14.357 ± 38.344 | 49.172 ± 90.294 | 0.000 | 0.174 | ||
Mb(µg/L) | 6.673 ± 5.176 | 11.440 ± 35.630 | 0.104 | 8.234 ± 19.045 | 34.481 ± 219.515 | 0.000 | 0.956 | ||
Tn(µg/L) | 3.279 ± 2.815 | 2.879 ± 2.844 | 0.278 | 3.493 ± 2.782 | 2.696 ± 2.870 | 0.057 | 0.413 | ||
LDH (u/L) | 172.169 ± 58.910 | 213.429 ± 87.814 | 0.000 | 193.202 ± 58.210 | 269.167 ± 131.487 | 0.000 | 0.000 | ||
CK (u/L) | 57.192 ± 41.249 | 58.817 ± 75.964 | 0.003 | 55.940 ± 68.155 | 85.376 ± 133.713 | 0.364 | 0.423 | ||
CK-MB (u/L) | 9.233 ± 6.598 | 10.957 ± 9.737 | 0.001 | 8.793 ± 4.359 | 10.668 ± 8.066 | 0.030 | 0.905 | ||