Table 1 Immunological comparison of N-TVV and E-TVV mice. AU = arbitrary units; C1q = complement component C1q; and C3 = complement component 3
From: High throughput method for detecting murine brain atrophy using a clinical 3T MRI
Immunological Outcomes | Sham (N = 6) | TMEV-IDD (N = 10) | N-TVV(n = 5) vs. E-TVV (n = 5) |
|---|---|---|---|
Number of Viral Copies | |||
Brain (n = 5) | Negative | 5.7E + 04 | |
Spinal Cord (n = 5) | Negative | 9.9E + 06 | |
Binding Antibody to Theiler's Virus | |||
Serum (AU) | 0 | 7.9E + 05 ± 2.2E + 05 | p = 0.547 |
CSF (AU) | 0 | 6.1E + 04 ± 5.9E + 04 | p = 0.134 |
IgG mRNA (2^-ΔCT) | |||
Brain | 1.8E-6 ± 1.1E-6 | 1.1E-3 ± 7.7E-4 | p = 0.304 |
Spinal Cord | 8.9E-4 ± 6.1E-4 | 2.3E-2 ± 3.2E-2 | p = 0.315 |
Complement Factors (2^-ΔCT) | |||
C1q—Spinal Cord | 6.6E-3 ± 2.4E-3 | 1.9E-2 ± 1.5E-2 | p = 0.0966 |
C3—Spinal Cord | 1.9E-2 ± 4.0E-3 | 3.1E-2 ± 1.5E-2 | p = 0.837 |