A novel radiomics based on multi-parametric magnetic resonance imaging for predicting Ki-67 expression in rectal cancer: a multicenter study

Table 3 Comparison of Clinical and imaging characteristics with different Ki67 status in three cohorts

Characteristic	Training		P1	In-valid		P2	Ex-valid		P3
	Ki67 (L)	Ki67 (H)		Ki67 (L)	Ki67 (H)		Ki67 (L)	Ki67 (H)
	(n = 37)	(n = 102)		(n = 14)	(n = 46)		(n = 10)	(n = 50)
Age(y)	63.27 ± 12.25	64.02 ± 11.1	0.733	66.29 ± 12.41	63.46 ± 13.64	0.491	67.6 ± 11.71	68.62 ± 9.45	0.766
Sex			0.695			0.751			0.47
F	13	41		4	17		2	19
M	24	61		10	29		8	31
CEA			0.562			0.759			0.485
Negative	14	46		7	19		5	32
Positive	23	56		7	27		5	18
NC			0.096			0.777			0.709
Yes	7	35		4	17		2	15
No	30	67		10	29		8	35
Location			0.568			0.135			0.687
Upper	5	21		5	8		3	13
Middle	15	42		3	23		4	27
Low	17	39		6	15		3	10
LD(mm)	44.0(33.35)	42.6(24.5)	0.746	42.2(42.5)	45.0(30.0)	0.975	43.5(39.5)	49.7(33.2)	0.974
ID(mm)	14.7(6.5)	16.3(5.15)	0.376	12.4(6.8)	19.0(7.5)	0.304	13.2(4.6)	16.0(6.35)	0.008
CIR(%)	68.5(42.5)	90.0(50.0)	0.021	75.0(50.0)	80.0(50.0)	0.809	84.1(33.0)	85.0(33.1)	0.861
ADC value	0.89 ± 0.20	0.78 ± 0.17	0.001	0.87 ± 0.94	0.77 ± 0.13	0.01	0.86 ± 0.09	0.78 ± 0.1	0.01
EP			0.702			0.759			1
Mild/Moderate	20	50		6	17		5	23
Obvious	17	52		8	29		5	27
mrT stage			0.001			0.036			0.003
T1	10	6		2	2		4	2
T2	13	23		5	10		4	18
T3	8	49		7	16		2	22
T4	6	24		0	18		0	8
mrN stage			0.038			0.015			0.362
N0	27	62		11	16		8	28
N1	2	25		2	17		1	13
N2	8	15		1	13		1	9
rM stage			0.112			1			0.577
Negative	37	93		13	40		10	44
Positive	0	9		1	6		0	6
mrCRM			0.043			0.154			0.04
Negative	30	64		13	33		9	27
Positive	7	38		1	13		1	23

Sex, CEA, Neoadjuvant chemotherapy, tumor location, EP, mrT stage, mrN stage, rM stage, mrCRM status between two group was compared by Chi-square test. After homogeneity test, T-test was used to compared with Age, and ADC values. Man-Whitney U test was used to compared with CIR, LD, ID
In-valid Internal validation, Ex-valid External validation, EP Enhancement pattern

ISSN: 1471-2342