Table 4 Logistic regression analysis for best radiomic feature set showing statistical difference between observation and radiation treatment groups in meningioma patients

Image

Radiomic features

MI

R²

P

AUC

OR (95% CI)

P

AUC

T1WI

squareroot_firstorder_Kurtosis

0.171

0.25

0.005

0.791

4.45 (2.10–9.45)

< 0.0001

0.79

CE-FLALR

exponential_gldm_SmallDependenceLowGrayLevelEmphasis

0.146

0.151

0.048

0.733

4.44 (1.97–10.01 )

< 0.0001

0.73

square_gldm_SmallDependenceLowGrayLevelEmphasis

0.158

0.142

0.048

0.765

square_glszm_ZoneEntropy

0.1

0.14

0.048

0.71

CE-T1WI

logarithm_glcm_Idn

0.152

0.264

< 0.0001

0.805

3.39 (1.51–7.57)

0.003

0.80

wavelet-LLL_firstorder_Kurtosis

0.169

0.25

< 0.0001

0.824

2.05 (1.06–3.98)

0.034

original_glszm_GrayLevelNonUniformityNormalized

0.082

0.086

0.007

0.639

1.85 (1.10–3.12)

0.021

logarithm_firstorder_Skewness

0.178

0.0238

< 0.0001

0.786

wavelet-LLL_glcm_Idmn

0.123

0.182

< 0.0001

0.744

wavelet-LHL_glcm_Idmn

0.1

0.151

0.0003

0.698

original_shape_Compactness2

0.086

0.142

0.0005

0.719

logarithm_ngtdm_Strength

0.1

0.125

0.001

0.744

logarithm_glszm_SmallAreaEmphasis

0.08

0.073

0.017

0.67

wavelet-HLH_glcm_MCC

0.041

0.066

0.026

0.627

T1WI + T2WI + FLAIR + CE-T1WI + CE-FLAIR

original_shape_SphericalDisproportion

0.067

0.071

0.012

0.669

2.35 (1.21–4.58)

0.012

0.87

wavelet-LLL_glcm_Idmn

0.062

0.066

0.012

0.662

2.49 (1.24-5.00)

0.010

square_glcm_Idmn

0.046

0.051

0.032

0.651

2.10 (1.21–3.64)

0.008

wavelet-HLL_glcm_Correlation

0.044

0.055

0.028

0.659

1.83 (1.12–2.98)

0.016

square_firstorder_10Percentile

0.043

0.057

0.012

0.601

1.59 (1.04–2.43)

0.033

wavelet-HHH_glszm_SizeZoneNonUniformityNormalized

0.036

0.047

0.040

0.638

1.46 (0.99–2.16)

0.060

wavelet-HLH_gldm_LargeDependenceEmphasis

0.049

0.052

0.032

0.642

1.42(0.93–2.18)

0.104

wavelet-LHL_gldm_DependenceEntropy

0.062

0.056

0.026

0.634

1.59 (0.90–2.82)

0.109

wavelet-LHL_glrlm_LongRunHighGrayLevelEmphasis

0.05

0.049

0.037

0.606

wavelet-HHL_glrlm_RunEntropy

0.058

0.048

0.040

0.613