From: Changes in radiomic and radiologic features in meningiomas after radiation therapy
Variable | Observation group (n = 100) | Treatment group (n = 62) | P Value | |
---|---|---|---|---|
Patient age (y)* | 69 ± 12 (40 ~ 98) | 64 ± 10 (43 ~ 83) | < 0.001 | |
No. of men No. of women | 27 (27) 73 (73) | 15 (24.2) 47 (75.8) | 0.57 | |
Follow up period (y)* | 2.9 ± 2.5 | 3.0 ± 2.3 | 0.87 | |
Post treatment period (y)* | 2.6 ± 2.2 | 0.38 | ||
Total radiation dose† | 0 | 1400 (400–2800) | ||
Location (No.) (%) | < 0.0001 | |||
Parasagittal or falx cerebri | 76 (76) | 32 (51.6) | ||
Anterior cranial fossa | 6 (6) | 2 (3.2) | ||
Cerebellopontine angle | 3 (3) | 9 (14.5) | ||
Cerebellar tentorium | 3 (3) | 1 (1.6) | ||
Cavernous sinus | 2 (2) | 3 (4.8) | ||
Posterior fossa | 2 (2) | 6 (9.7) | ||
Olfactory bulb | 2 (2) | 3 (4.8) | ||
Lateral ventricle | 2 (2) | 2 (3.2) | ||
Middle cranial fossa | 2 (2) | 1 (1.6) | ||
Prepontine cistern | 1 (1) | 0 (0) | ||
Foramen magnum | 1 (1) | 0 (0) | ||
Sella | 0 (0) | 1 (1.6) | ||
Straight sinus | 0 (0) | 1 (1.6) | ||
Optic sheath | 0 (0) | 1 (1.6) | ||
Imaging features (No.) (%) | Description | |||
CSF cleft | Perimeter of CSF between the tumor and brain | 88 (88) | 47 (75.2) | < 0.001 |
Mass effect | Shift in normal brain parenchyma due to tumor | 25 (25) | 23 (36.8) | 0.02 |
Intratumoral heterogeneity | Heterogeneity in hyperintensity of MRI signal throughout tumor | 22 (11) | 7 (11.2) | 0.87 |
Skull hyperostosis | Bony overgrowth adjacent to tumor | 14 (14) | 14 (22.4) | 0.07 |
Multifocality | Non-contiguous growth of tumor | 5 (5) | 3 (4.8) | 0.95 |
Bony invasion | Appearance of tumor invading the skull | 3 (3) | 12 (19.2) | < 0.0001 |
Midline shift | Shift of the brain past midline | 3 (3) | 3 (4.8) | 0.26 |
Necrosis/Hemorrhage | Presence of necrosis or hemorrhage | 3 (3) | 5 (8.0) | 0.04 |
Spiculation | Irregularities in tumor shape and border | 3 (3) | 3 (4.8) | 0.39 |
Cystic component | Fluid filled cysts within the tumor | 3 (3) | 2 (3.2) | 0.76 |
Sinus invasion | Presence of venous sinus invasion | 2 (2) | 10 (16) | < 0.0001 |
Recurrence | Recurrent at presentation | 1 (1) | 4 (6.4) | 0.01 |