Table 3 Comparison of different studies reporting cryoablation for lung nodules

Patient numbers

45

40

128

41

10

71

117

Origin of Targets: nodules = mixed origin

lung

mets

mets

nodules

Head and neck mets

nodules

nodules

Mean tumor size(cm)

1.9

1.4

1.0 ± 0.6

1.48

1.6

1.28

1.4

Follow up protocol: baseline/ months after baseline

1 M/3 M

3 M/3 M

1 M/3 M

3 M/3 M

1 day or 1 M/3 M

1 M/3 M

1WK or 1 M/3 M

Anesthesia Methods

(LA local anesthesia

GA General anesthesia)

GA

GA67%

conscious sedation

33%

GA 69%

Conscious Sedation 29%

LA 2%

LA

Concious

Sedation/GA

Pentazzo-cine+

Atropine + LA

LA

needle size(Gauge/G)

13G/ 16G

17G/13G

17G /15G/

13G

17G

16G

15G

13G/

12G

Pneumothorax per procedure %

(N/A non applicable)

51

 N/A

N/A

52

38.2

 N/A

61.7

Pneumothorax require drainage per procedure% (N/A non applicable)

12.8

18.8

26

11.3

14.3

 N/A

17.6

Hemoptysis per procedure % (N/A non applicable)

40

 N/A

N/A

12.9

33.3

 N/A

36.8

Overall Survival 1year%

89.4

97.5

97.6

97

 N/A

N/A

N/A

Overall Survival 2year%

Around > 85^a

84.3

86.6

94

 N/A

N/A

N/A

Overall Survival 3 year%

78.1

63.2

 N/A

82

N/A

N/A

N/A

Overall Survival 5 year%

67.8

46.7

 N/A

N/A

N/A

N/A

N/A

Response Criteria

Radiology &PET

M-RECIST

M-RECIST

M-RECIST

PET/CT and CT

Nadir+/- CE^b

N/A

Tumor progression free rate 1Y%

N/A

94.2

85.1

86.2

88(estimated)

80.4

 N/A

Tumor progression free rate 2Y%

N/A

N/A

77.2

77

65(estimated)

69.0

 N/A

Tumor progression free rate 3Y%

N/A

83.3

 N/A

74

N/A

67.7

 N/A

Tumor progression free rate 5Y%

63.8^c

75

N/A

N/A

N/A

N/A

N/A