From: Predicting response to CCRT for esophageal squamous carcinoma by a radiomics-clinical SHAP model
Feature | Category | Training set (N / Mean ± Std) | Testing set (N / Mean ± Std) | Validation set (N / Mean ± Std) | ||||||
---|---|---|---|---|---|---|---|---|---|---|
 |  | Response (n = 47) | Non-response (n = 23) | P -value | Response (n = 16) | Non-response (n = 8) | P-value | Response (n = 4) | Non-response (n = 7) | P -value |
Sex | Â | Â | Â | 1 | Â | Â | 1 | Â | Â | 0.98 |
 | Male | 38 | 19 |  | 14 | 8 |  | 2 | 6 |  |
 | Female | 9 | 4 |  | 2 | 0 |  | 2 | 1 |  |
T stage | Â | Â | Â | 0.05 | Â | Â | Â | Â | Â | Â |
 | T1-2 | 5 | 7 |  | 5 | 0 | 0.12 | 0 | 3 | 0.3 |
 | T3 | 37 | 16 |  | 7 | 7 |  | 3 | 4 |  |
 | T4 | 5 | 0 |  | 4 | 1 |  | 1 | 0 |  |
N stage | Â | Â | Â | 0.88 | Â | Â | Â | Â | Â | Â |
 | N0 | 12 | 7 |  | 2 | 1 | 0.84 | 0 | 3 | 0.46 |
 | N1 | 10 | 4 |  | 6 | 2 |  | 2 | 1 |  |
 | N2-3 | 25 | 12 |  | 8 | 5 |  | 2 | 3 |  |
M stage | M0 | 47 | 23 | 1 | 16 | 8 | 1 | 4 | 7 | 1 |
TNM Stage | Â | Â | Â | 0.27 | Â | Â | 0.26 | Â | Â | 0.53 |
 | II | 14 | 8 |  | 4 | 0 |  | 0 | 0 |  |
 | III | 28 | 15 |  | 7 | 6 |  | 3 | 4 |  |
 | IVA | 5 | 0 |  | 5 | 2 |  | 1 | 3 |  |
Age (year) |  | 67.45 ± 9.01 | 66.17 ± 8.09 | 0.27 | 66.75 ± 8.01 | 70.75 ± 6.27 | 0.20 | 67.25 ± 12.92 | 67.00 ± 8.00 | 0.97 |
BMI (kg/m2) |  | 22.30 ± 3.08 | 22.94 ± 3.52 | 0.45 | 21.12 ± 2.40 | 22.32 ± 3.36 | 0.48 | 25.24 ± 1.99 | 22.73 ± 3.06 | 0.92 |
BSA (m2) |  | 1.6 ± 0.14 | 1.63 ± 0.18 | 0.66 | 1.61 ± 0.14 | 1.58 ± 0.13 | 0.44 | 1.64 ± 0.14 | 1.65 ± 0.19 | 0.22 |
HGB (g/l) |  | 128.28 ± 14.62 | 126.78 ± 16.56 | 0.71 | 121.75 ± 17.43 | 116.13 ± 22.50 | 0.43 | 126.28 ± 22.50 | 118.29 ± 20.36 | 0.85 |
CA72-4 (IU/ml) |  | 4.91 ± 9.45 | 16.80 ± 39.17 | 0.29 | 2.58 ± 2.37 | 3.06 ± 2.48 | 0.54 | 7.53 ± 8.29 | 21.85 ± 38.32 | 0.40 |
CYFRA21-1 (ng/ml) |  | 7.07 ± 6.20 | 18.80 ± 59.84 | 0.24 | 5.49 ± 3.02 | 5.19 ± 5.04 | 0.26 | 4.68 ± 2.02 | 6.46 ± 4.75 | 0.71 |
SCC (ng/ml) |  | 5.25 ± 14.33 | 2.56 ± 1.52 | 0.52 | 4.11 ± 3.94 | 3.83 ± 3.59 | 0.95 | 2.51 ± 0.53 | 2.18 ± 0.49 | 0.85 |
CEA (ng/ml) |  | 2.91 ± 2.56 | 2.96 ± 1.46 | 0.25 | 2.25 ± 0.91 | 2.69 ± 1.10 | 0.58 | 2.77 ± 1.18 | 3.35 ± 2.60 | 0.45 |
CA19-9 (U/ml) |  | 13.01 ± 13.18 | 12.19 ± 8.67 | 0.56 | 29.78 ± 81.64 | 10.48 ± 7.19 | 0.93 | 14.68 ± 8.63 | 5.24 ± 2.52 | 0.06 |
LL(cm) |  | 7.74 ± 2.69 | 2.76 ± 2.17 | 0.14 | 9.13 ± 3.52 | 7.06 ± 2.76 | 0.23 | 7.88 ± 2.60 | 7.50 ± 3.37 | 0.57 |
MDL(cm) |  | 3.76 ± 1.25 | 2.95 ± 0.86 | 0.01 | 4.51 ± 1.10 | 3.11 ± 1.18 | 0.02 | 4.16 ± 0.86 | 2.61 ± 0.82 | 0.04 |