Table 2 CE-CT imaging features between high Ki-67 expression and low Ki-67 expression groups of training set, internal test set and external validation set
From: Added value of CE-CT radiomics to predict high Ki-67 expression in hepatocellular carcinoma
Characteristic | Training set (n = 120) | Internal test set (n = 51) | External validation set (n = 37) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Low Ki67(n = 49) | High Ki67(n = 71) | n | P value | Low Ki67(n = 21) | High Ki67(n = 30) | n | P value | Low Ki67(n = 12) | High Ki67(n = 25) | n | P value | ||
Size | > 5 cm | 19(29.7) | 45(70.3) | 64 | 0.01 | 13(48.1) | 14(51.9) | 27 | 0.394 | 5(26.3) | 14(73.7) | 19 | 0.495 |
≤ 5 cm | 30(53.6) | 26(46.4) | 56 | 8(33.3) | 16(66.7) | 24 | 7(38.9) | 11(61.1) | 18 | ||||
Non-rim APHE | Yes | 33(32.7) | 68(67.3) | 101 | < 0.001 | 13(34.2) | 25(65.8) | 38 | <0.109 | 6(22.2) | 21(77.8) | 27 | <0.109 |
No | 16(84.2) | 3(15.8) | 19 | 8(61.5) | 5(38.5) | 13 | 6(60.0) | 4(40.0) | 10 | ||||
Non-peripheral washout | Yes | 38(35.8) | 68(64.2) | 106 | 0.003 | 18(42.9) | 24(57.1) | 42 | 0.72 | 8(33.3) | 16(66.7) | 24 | 0.874 |
No | 11(78.6) | 3(21.4) | 14 | 3(33.3) | 6(66.7) | 9 | 4(30.8) | 9(69.2) | 13 | ||||
Corona enhancement | Yes | 7(35.0) | 13(65.0) | 20 | 0.625 | 4(36.4) | 7(63.6) | 11 | 0.746 | 0(0.0) | 1(100.0) | 1 | 0.482 |
No | 42(42.0) | 58(58.0) | 100 | 17(42.5) | 23(57.5) | 40 | 12(33.3) | 24(66.7) | 36 | ||||
Nodule-in-nodule architecture | Yes | 7(58.3) | 5(41.7) | 12 | 0.161 | 1(33.3) | 2(66.7) | 3 | 0.776 | 2(22.2) | 7(77.8) | 9 | 0.687 |
No | 42(38.9) | 66(61.1) | 108 | 20(41.7) | 28(58.3) | 48 | 10(35.7) | 18(64.3) | 28 | ||||
Mosaic architecture | Yes | 33(36.3) | 58(63.7) | 91 | 0.057 | 17(47.2) | 19(52.8) | 36 | 0.221 | 2(18.2) | 9(81.8) | 11 | 0.279 |
No | 16(55.2) | 13(44.8) | 29 | 4(26.7) | 11(73.3) | 15 | 10(38.5) | 16(61.5) | 26 | ||||
Scar sign | Yes | 2(28.6) | 5 (71.4) | 7 | 0.398 | 1(20.0) | 4(80.0) | 5 | 0.391 | 3(27.3) | 8(72.7) | 11 | 0.722 |
No | 47(41.6) | 66(58.4) | 113 | 20(43.5) | 26(56.5) | 46 | 9(34.6) | 17(65.4) | 26 | ||||
Tumor rupture | Yes | 1(33.3) | 2(66.7) | 3 | 0.637 | 0(0.0) | 2(100.0) | 2 | 0.506 | 0(0.0) | 0(0.0) | -- | |
No | 48(41.0) | 69(59.0) | 117 | 21(42.9) | 28(57.1) | 49 | 12(32.4) | 25(67.6) | 37 | ||||
Intra-tumoral necrosis | Yes | 21(32.8) | 43(67.2) | 64 | 0.065 | 15(42.9) | 20(57.1) | 35 | 0.768 | 4(28.6) | 10(71.4) | 14 | 0.735 |
No | 28(50.0) | 28(50.0) | 56 | 6(37.5) | 10(62.5) | 16 | 8(34.8) | 15(65.2) | 23 | ||||
TTPVI | Yes | 1(5.0) | 19(95.0) | 20 | < 0.001 | 6(28.6) | 15(71.4) | 21 | 0.156 | 0(0.0) | 4(100.0) | 4 | 0.142 |
No | 48(48.0) | 52(52.0) | 100 | 15(50.0) | 15(50.0) | 30 | 12(36.4) | 21(63.3) | 33 | ||||
PVTT | Yes | 8(20.5) | 31(79.5) | 39 | 0.003 | 7(46.7) | 8(53.3) | 15 | 0.757 | 0(0.0) | 3(100.0) | 3 | 0.537 |
No | 41(50.6) | 40(49.4) | 81 | 14(38.9) | 22(61.1) | 36 | 12(35.3) | 22(64.7) | 34 | ||||
peritumoral satellite | Yes | 6(21.4) | 22(78.6) | 36 | 0.027 | 5(41.7) | 7(58.3) | 12 | 0.969 | 0(0.0) | 0(0.0) | -- | |
No | 43(46.7) | 49(53.3 | 135 | 16(41.0) | 23(59.0) | 39 | 12(32.4) | 25(67.6) | 37 | ||||