Detecting lesion-specific ischemia in patients with coronary artery disease with computed tomography fractional flow reserve measured at different sites

Cai, Zhaoxi; Yu, Taihui; Yang, Zehong; Hu, Huijun; Lin, Yongqing; Zhang, Haifeng; Chen, Meiwei; Shi, Guangzi; Shen, Jun

doi:10.1186/s12880-023-01031-4

Table 4 ROC analysis of CCTA, FFR_CT-1 cm, FFR_CT-2 cm, FFR_CT-3 cm, FFR_CT-lowest and their combination in identifying lesion-specific ischemia on per-vessel basis

From: Detecting lesion-specific ischemia in patients with coronary artery disease with computed tomography fractional flow reserve measured at different sites

Per-vessel	Accuracy (%)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	AUC	P value
CCTA (DS ≥ 50%)	47.2 (34/72) [36.1, 58.6]	100.0(25/25) [83.4, 100.0]	19.1(9/47) [9.6, 33.7]	39.7(25/63) [27.8, 52.8]	100.0 (9/9) [62.9, 100.0]	0.578 [0.443, 0.713]	0.277
FFR_CT-1 cm	81.9(59/72) [79.5, 89.1]	60.0(15/25) [38.9, 78.2]	93.6(44/47) [81.4, 98.3]	83.3(15/18) [57.7, 95.6]	81.5(44/54) [68.1, 90.3]	0.768 [0.640, 0.896]	0.0001
FFR_CT-2 cm	87.5(63/72) [77.9 93.3]	80.0(20/25) [58.7, 92.4]	91.5(43/47) [78.7, 97.2]	83,3(20/24) [61.8, 94.5]	89.6(43/48) [76.6, 96.1]	0.857 [0.754, 0.961]	0.0001
FFR_CT-3 cm	86.1(62/72) [76.3 92.3]	84.0(21/25) [63.1, 94.7]	87.2(41/47) [71.6, 93.5]	77.8(21/27) [54.8,88.6]	88.9(41/45) [77.9, 88.6]	0.856 [0.756, 0.957]	0.0001
FFR_CT-lowest	73.6(53/72) [62.4, 82.4]	88.0(22/25) [67.7, 96.8]	66.0(31/47) [50.6, 78,7]	58.0(22/38) [40.9, 73.3]	91.2(31/34) [75.2, 97.7]	0.770 [0.657, 0.882]	0.0001
FFR_CT-1 cm + FFR_CT-2 cm	87.5(63/72) [77.9 93.3]	80.0(20/25) [58.7, 92.4]	91.5(43/47) [78.7, 97.2]	83,3(20/24) [61.8, 94.5]	89.6(43/48) [76.6, 96.1]	0.857 [0.754, 0.961]	0.0001
FFR_CT-2 cm + FFR_CT-3 cm	87.5(63/72) [77.9 93.3]	80.0(20/25) [58.7, 92.4]	91.5(43/47) [78.7, 97.2]	83,3(20/24) [61.8, 94.5]	89.6(43/48) [76.6, 96.1]	0.871 [0.774, 0.969]	0.0001
FFR_CT-3 cm + FFR_CT-lowest	86.1(62/72) [76.3 92.3]	84.0(21/25) [63.1, 94.7]	87.2(41/47) [71.6, 93.5]	77.8(21/27) [54.8,88.6]	88.9(41/45) [77.9, 88.6]	0.857 [0.756, 0.957]	0.0001
FFR_CT-1 cm + FFR_CT-2 cm + FFR_CT-3 cm	87.5(63/72) [77.9 93.3]	80.0(20/25) [58.7, 92.4]	91.5(43/47) [78.7, 97.2]	83,3(20/24) [61.8, 94.5]	89.6(43/48) [76.6, 96.1]	0.871 [0.774, 0.969]	0.0001
FFR_CT-2 cm + FFR_CT-3 cm + FFR_CT- lowest	87.5(63/72) [77.9 93.3]	80.0(20/25) [58.7, 92.4]	91.5(43/47) [78.7, 97.2]	83,3(20/24) [61.8, 94.5]	89.6(43/48) [76.6, 96.1]	0.872 [0.774, 0.970]	0.0001
CCTA + FFR_CT-1 cm	81.9(59/72) [79.5, 89.1]	60.0(15/25) [38.9, 78.2]	93.6(44/47) [81.4, 98.3]	83.3(15/18) [57.7, 95.6]	81.5(44/54) [68.1, 90.3]	0.785 [0.664, 0.905]	0.0001
CCTA + FFR_CT-2 cm	87.5(63/72) [77.9 93.3]	80.0(20/25) [58.7, 92.4]	91.5(43/47) [78.7, 97.2]	83,3(20/24) [61.8, 94.5]	89.6(43/48) [76.6, 96.1]	0.868 [0.770, 0.967]	0.0001
CCTA + FFR_CT-3 cm	86.1(62/72) [76.3 92.3]	84.0(21/25) [63.1, 94.7]	87.2(41/47) [71.6, 93.5]	77.8(21/27) [54.8,88.6]	88.9(41/45) [77.9, 88.6]	0.863 [0.765, 0.961]	0.0001
CCTA + FFR_CT-lowest	73.6(53/72) [62.4, 82.4]	88.0(22/25) [67.7, 96.8]	66.0(31/47) [50.6, 78,7]	58.0(22/38) [40.9, 73.3]	91.2(31/34) [75.2, 97.7]	0.798 [0.695, 0.902]	0.0001

PPV positive predictive value, NPV negative predictive value, CCTA coronary computed tomography angiography, DS diameter stenosis, FFR_CT-1 cm FFR_CT measured at 1 cm distal to the lower border of the target lesion, FFR_CT-2 cm FFR_CT measured at 2 cm distal to the lower border of the target lesion, FFR_CT-3 cm FFR_CT measured at 3 cm distal to the lower border of the target lesion, FFR_CT-lowest lowest FFR_CT value in the distal vessel tip. Data in parentheses are number of vessels. Data in brackets are 95% confidence interval

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