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Table 3 Discriminative performance of pharmacokinetic parameters

From: High-temporal resolution DCE-MRI improves assessment of intra- and peri-breast lesions categorized as BI-RADS 4

 

AUC

95% CI

SEN (%)

SPC (%)

Cutoff

Youden

P

High-temporal-resolution DCE-MRI group

Lesion_Ktrans

0.866

0.756–0.939

89.7

78.3

> 0.214

0.680

< 0.0001

Lesion_Kep

0.929

0.834–0.979

89.7

95.7

> 0.618

0.854

< 0.0001

Lesion_Ve

0.691

0.561–0.802

87.2

60.8

> 0.325

0.480

0.025

Lesion_Vp

0.872

0.762–0.943

69.2

91.3

> 0.009

0.605

< 0.0001

Peri_Ktrans

0.733

0.605–0.837

97.4

43.5

> 0.049

0.409

0.0007

Peri_Kep

0.810

0.690–0.898

92.3

65.2

> 0.240

0.575

< 0.0001

Peri_Vp

0.857

0.745–0.933

82.1

78.3

> 0.008

0.603

< 0.0001

Low-temporal-resolution DCE-MRI group

Lesion_Kep

0.767

0.658–0.855

69.6

78.1

> 0.334

0.477

< 0.0001

Peri_Vp

0.726

0.613–0.821

84.8

59.4

≤ 0.548

0.442

0.0004

BPE_Ktrans

0.687

0.572–0.787

80.4

59.4

≤ 2.369

0.398

0.005

BPE_Vp

0.707

0.593–0.805

89.1

56.2

≤ 0.639

0.454

0.0014

  1. AUC area under the curve, BPE background parenchyma enhancement, CI confidence interval, Peri perilesional, SEN sensitivity, SPC specificity