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Table 3 Univariate and multivariate Logistic regression analysis of predictive factors for mediastinal lymph node in NSCLC patients

From: The value on SUV-derived parameters assessed on 18F-FDG PET/CT for predicting mediastinal lymph node metastasis in non-small cell lung cancer

Characteristics

Univariate analysis

OR (95% CI)

p value

Multivariate regression

OR (95% CI)

p value

SUVmax of mediastinal lymph node

    

< 2.49

Reference

 

Reference

 

≥ 2.49

6.947 (3.551–13.591)

 < 0.001

7.215 (3.326–15.649)

 < 0.001

Primary-tumor SUVmax

    

< 4.11

Reference

   

≥ 4.11

5.600 (2.272–13.801)

 < 0.001

  

Primary-tumor SUVpeak

    

< 2.92

Reference

 

Reference

 

≥ 2.92

6.021 (2.444–14.829)

 < 0.001

5.717 (2.094–15.605)

0.001

Primary-tumor SUVmean

    

< 2.39

Reference

   

≥ 2.39

5.077 (2.058–12.525)

 < 0.001

  

Primary-tumor MTV (cm3)

    

< 30.88

Reference

   

≥ 30.88

2.388 (1.244–4.583)

0.009 b

  

Primary-tumor TLG

    

< 83.53

Reference

   

≥ 83.53

2.737 (1.460–5.128)

 < 0.002

  

Degree of primary-tumor solidity

    

Partial solid

Reference

   

solid

5.429 (2.321–12.697)

 < 0.001

  

CEA (ng/ml)

    

< 3.94

Reference

 

Reference

 

≥ 3.94

3.394 (1.800–6.400)

 < 0.001

2.467 (1.182–5.149)

0.016

CYFRA21-1 (ng/ml)

    

< 2.10

Reference

   

≥ 2.10

2.642 (1.116–6.252)

0.027

  

CA19-9 (U/ml)

    

< 16.6

Reference

   

≥ 16.6

2.234 (1.168–4.273)

0.015

  

SCC (ng/ml)

    

< 16.6

2.052 (1.023–4.113)

0.043

4.795 (2.019–11.388)

 < 0.001

≥ 16.6

Reference

 

Reference

 

NSE (ng/ml)

    

< 14.66

Reference

   

≥ 14.66

1.976 (1.051–3.713)

0.034

  
  1. NSCLC, non-small cell lung cancer; OR, odds ratio; SUV, standardized uptake value; SUVmax, maximum SUV; SUVpeak, peak of SUV; SUVmean, average of SUV; MTV, metabolic tumor volume; TLG, total lesion glycolysis; CEA, carcinoembryonic antigen; CYFRA21-1, cytokeratin 19 fragment; CA19-9, carbohydrate antigen 19-9; SCC, squamous cell carcinoma antigen; NSE, neuron-specific enolase