Table 2 The tumour B-mode、RTE、CDFI ultrasound features per molecular subtype
From: Multimodal ultrasound features of breast cancers: correlation with molecular subtypes
Molecular Subtype | Total [n = 85] | Luminal A [n = 36] VS. Other Types | Luminal B [n = 20] VS. Other Types | HER2+ [n = 16] VS. Other Types | TNBC [n = 13] VS. Other Types | ||||
|---|---|---|---|---|---|---|---|---|---|
N | Luminal A | p | Luminal B | p | HER2 | p | TNBC | p | |
Tumor size (cm, Mean ± SD) | 2.33 ± 1.14 | 1.72 ± 0.73 | 2.61 ± 1.23 | 3.09 ± 1.19 | 2.67 ± 1.14 | ||||
Shape | 0.516 | 0.730 | 0.115 | 0.362 | |||||
Oval/Round | 11(12.9) | 6(16.7) | 2(10.0) | 0(0.0) | 3(23.1) | ||||
Irregular | 74(87.1) | 30(83.3) | 18(90.0) | 16(100) | 10(76.9) | ||||
Orientation | 0.014 | 1.000 | 0.111 | 0.198 | |||||
Parallel | 73(85.9) | 27(75.0) | 17(85.0) | 16(100) | 13(100) | ||||
Non-parallel | 12(14.1) | 9(25.0) | 3(15.0) | 0(0.0) | 0(0.0) | ||||
Margin | 0.022 | 0.330 | 0.024 | 0.682 | |||||
Circumscribed | 0(0.0) | 0(0.0) | 0(0.0) | 0(0.0) | 0(0.0) | ||||
Microlobulated | 8(9.4) | 1(2.8) | 1(5.0) | 5(31.2) | 1(7.7) | ||||
Spiculated | 24(28.2) | 16(44.4) | 3(15.0) | 3(18.8) | 2(15.4) | ||||
Angular | 41(48.3) | 15(41.7) | 12(60.0) | 6(37.5) | 8(61.5) | ||||
Indistinct | 12(14.1) | 4(11.1) | 4(20.0) | 2(12.5) | 2(15.4) | ||||
Echo pattern | 0.105 | 1.000 | 0.003 | 1.000 | |||||
Hyperechoic | 3(3.5) | 2(5.6) | 0(0.0) | 1(6.3) | 0(0.0) | ||||
Isoechoic | 5(5.9) | 0(0.0) | 1(5.0) | 4(25.0) | 0(0.0) | ||||
Hypoechoic | 77(90.6) | 34(94.4) | 19(95.0) | 11(68.7) | 13(100) | ||||
Posterior features | 0.330 | 1.000 | 0.338 | 0.115 | |||||
No posterior features | 49(57.6) | 21(58.3) | 12(60.0) | 8(50.0) | 8(61.5) | ||||
Combined pattern | 6(7.1) | 1(2.8) | 1(5.0) | 2(12.5) | 2(15.4) | ||||
Enhancement | 2(2.4) | 0(0.0) | 0(0.0) | 1(6.3) | 1(7.7) | ||||
Shadowing | 28(32.9) | 14(38.9) | 7(35.0) | 5(31.2) | 2(15.4) | ||||
Calcifications | 0.004 | 0.051 | 0.180 | 1.000 | |||||
No | 28(32.9) | 18(50.0) | 3(15.0) | 3(18.8) | 4(30.8) | ||||
Yes | 57(67.1) | 18(50.0) | 17(85.0) | 13(81.2) | 9(69.2) | ||||
RTE | 0.001 | 0.003 | 0.280 | 0.339 | |||||
1 | 0(0.0) | 0(0.0) | 0(0.0) | 0(0.0) | 0(0.0) | ||||
2 | 44(51.8) | 8(22.2) | 13(65.0) | 12(75.0) | 11(84.6) | ||||
3 | 6(7.1) | 1(2.8) | 4(20.0) | 1(6.3) | 0(0.0) | ||||
4 | 19(22.3) | 13(36.1) | 3(15.0) | 2(12.5) | 1(7.7) | ||||
5 | 16(18.8) | 14(38.9) | 0(0.0) | 1(6.3) | 1(7.7) | ||||
CDFI | 0.004 | 0.097 | 0.039 | 0.007 | |||||
0 | 0(0.0) | 0(0.0) | 0(0.0) | 0(0.0) | 0(0.0) | ||||
1 | 11(13.0) | 9(25.0) | 2(10.0) | 0(0.0) | 0(0.0) | ||||
2 | 42(49.4) | 19(52.8) | 14(70.0) | 6(37.5) | 3(23.1) | ||||
3 | 32(37.6) | 8(22.2) | 4(20.0) | 10(62.5) | 10(76.9) | ||||