Quantitative muscle MRI displays clinically relevant myostructural abnormalities in long-term ICU-survivors: a case–control study

Table 3 Multivariate general linear model results of qMRI parameters between controls (CON) and patients (CIP)

q-MRI parameters	All muscles		Thigh muscles	Calf muscles
n muscles (PAT/CON)	98/300		28/160	70/140
T2 ms	∆ mean	2.6	0.01	3.33
T2 ms	p value	< 0.001*	0.957	< 0.001*
n muscles (PAT/CON)	164/300		52/160	112/140
FF %	∆ mean	0.79	0.71	2.2
FF %	p value	< 0.001*	< 0.001*	0.022*
FA	∆ mean	0.02	0.025	0.01
FA	p value	0.047*	0.352	0.429
MD [10⁻³ mm²/s]	∆ mean	0.1	0.06	0.11
MD [10⁻³ mm²/s]	p value	< 0.001*	0.001*	< 0.001*
λ₁ [10⁻³ mm²/s]	∆ mean	0.16	0.12	0.15
λ₁ [10⁻³ mm²/s]	p value	< 0.001*	< 0.001*	< 0.001*
RD [10⁻³ mm²/s]	∆ mean	0.07	0.03	0.1
RD [10⁻³ mm²/s]	p value	< 0.001*	0.009*	< 0.001*

Significant results are highlighted with * and expressed in bold. Significance level was calculated as p < 0.05. Δ-mean was calculated as: Mean of PAT value–Mean of CON value, for each parameter
FF, fat fraction; MD, mean diffusivity; FA, fractional anisotropy; RD, radial diffusivity; T2, water T2-time

ISSN: 1471-2342