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Table 3 Subgroup analysis for the diagnostic performance of DWI in detecting pulmonary lesions

From: Diagnostic performance of diffusion-weighted imaging versus 18F-FDG PET/CT in differentiating pulmonary lesions: an updated meta-analysis of comparative studies

Characteristics

Studies (n)

Pooled sensitivity (95% Cl)

Pooled specificity (95% Cl)

Total

11*

0.85 (0.77–0.90)

0.91 (0.82–0.96)

Year

  > 2011

6

0.85 (0.76–0.94)

0.87 (0.76–0.97)

  ≤ 2011

5

0.84 (0.74–0.94)

0.95 (0.89–1.00)

Design

 Prospective

6

0.85 (0.76–0.94)

0.89 (0.78–0.99)

 Retrospective

5

0.84 (0.74–0.94)

0.93 (0.86–0.99)

No. of nodules

  ≤ 100

7

0.87 (0.80–0.94)

0.91 (0.83–0.99)

  > 100

4

0.81 (0.69–0.92)

0.91 (0.82–1.00)

Magnetic strength

 3T

4

0.83 (0.71–0.94)

0.89 (0.78–1.00)

 1.5T

7

0.86 (0.78–0.94)

0.92 (0.85–0.99)

Lesion diameter**

 Only Nodules(≤ 3 cm)

4

0.74 (0.64–0.85)

0.91 (0.80–1.00)

 Nodules and Masses

3

0.87 (0.81–0.93)

0.93 (0.85–1.00)

Disease in the benign group

 Only inflammation

3

0.90 (0.82–0.98)

0.94 (0.86–1.00)

 Inflammation and tumors

8

0.82 (0.74–0.90)

0.90 (0.82–0.98)

Parameter

 ADC

10

0.84 (0.77–0.91)

0.91 (0.84–0.98)

 SI-CR

1

0.87 (0.68–1.00)

0.92 (0.73–1.00)

Reference standard

 His/Fol

8

0.82 (0.75–0.90)

0.88 (0.79–0.97)

 His

3

0.90 (0.81–0.99)

0.96 (0.91–1.00)

  1. Boldface type indicates P value is < 0.05 in subgroup analysis of sensitivity or specificity; His Histological, Fol Follow-up
  2. *A total of 10 studies were included but one study was counted twice due to use of both 1.5-T and 3.0-T MRI to conduct DWI on all patients, resulting in a total of 11 studies in the table
  3. **Four studies were excluded from this subgroup due to lack of information on lesion diameter