Skip to main content

Table 3 Performance of noninvasive parameters for the prediction of high-risk varices

From: Performance of spleen stiffness measurement by 2D-shear wave elastography in evaluating the presence of high-risk varices: comparative analysis of idiopathic portal hypertension versus hepatitis B virus

Variables

n(P)

Cutoff value

AUC

Sensitivity

Specificity

PPV

NPV

LR+

LR−

SS

         

 IPH

30 (34.88)

44.0

0.98 (0.92–1.00)

0.93 (0.78–0.99)

0.96 (0.88–1.00)

0.93 (0.78–0.98)

0.96 (0.88–0.99)

0.26 (0.07–1.02)

0.00 (0.00–0.00)

 HBV

47 (46.1)

35.2

0.96 (0.90–0.99)

1.00 (0.93–1.00)

0.82 (0.69–0.91)

0.82 (0.72–0.89)

0.98 (0.87–1.00)

0.06 (0.03–0.10)

0.00 (0.00–0.01)

LS

         

 IPH

30 (34.88)

9.1

0.81*** (0.71–0.88)

0.93 (0.78–0.99)

0.55 (0.42–0.69)

0.53 (0.45–0.60)

0.94 (0.80–0.98)

0.02 (0.02–0.03)

0.00 (0.00–0.01)

 HBV

47 (46.1)

17.7

0.72*** (0.62–0.81)

0.57 (0.42–0.71)

0.91 (0.80–0.97)

0.84 (0.69–0.93)

0.71 (0.64–0.78)

0.06 (0.03–0.15)

0.47 (0.00–0.01)

SS/LS

         

 IPH

30 (34.88)

4.1

0.62*** (0.51–0.73)

0.77 (0.58–0.90)

0.50 (0.36–0.64)

0.45 (0.37–0.53)

0.80 (0.67–0.89)

0.02 (0.01–0.02)

0.01 (0.00–0.01)

 HBV

47 (46.08)

2.5

0.73*** (0.64–0.82)

0.49 (0.34–0.64)

0.89 (0.78–0.96)

0.79 (0.63–0.90)

0.67 (0.60–0.73)

0.04 (0.02–0.10)

0.01 (0.00–0.01)

LSPS

         

 IPH

30 (34.88)

2.3

0.88* (0.80–0.94)

0.87 (0.69–0.96)

0.80 (0.68–0.90)

0.79 (0.64–0.89)

0.88 (0.79–0.93)

0.04 (0.03–0.08)

0.00 (0.00–0.00)

 HBV

43 (43.88)

3.9

0.94 (0.88–0.98)

0.88 (0.75–0.96)

0.95 (0.85–0.99)

0.93 (0.81–0.98)

0.91 (0.82–0.96)

0.16 (0.05–0.49)

0.00 (0.00–0.00)

PH risk score

         

 IPH

30 (34.88)

4.4

0.85** (0.76–0.92)

0.70 (0.51–0.85)

0.89 (0.78–0.96)

0.78 (0.61–0.89)

0.85 (0.76–0.91)

0.06 (0.03–0.14)

0.00 (0.00–0.01)

 HBV

43 (43.88)

3.8

0.95 (0.88–0.98)

0.98 (0.88–0.99)

0.89 (0.78–0.96)

0.88 (0.77–0.94)

0.98 (0.88–1.00)

0.09 (0.04–0.19)

0.00 (0.00–0.00)

Varices risk score

         

 IPH

30 (34.88)

0.9

0.89* (0.80–0.95)

0.80 (0.61–0.92)

0.88 (0.76–0.95)

0.77 (0.63–0.88)

0.89 (0.80–0.94)

0.06 (0.03–0.13)

0.00 (0.00–0.00)

 HBV

43 (43.88)

1.7

0.96 (0.90–0.99)

0.93 (0.81–0.99)

0.95 (0.85–0.99)

0.93 (0.82–0.98)

0.95 (0.85–0.98)

0.17 (0.06–0.51)

0.00 (0.00–0.00)

  1. Statistical quantifications were demonstrated with 95% CI, when applicable. AUC of SS was statistically compared with AUC of LS, SS/LS, LSPS, PH risk score and varices risk score, respectively
  2. SS, spleen stiffness; LS, liver stiffness; SS/LS, spleen stiffness-to-liver stiffness ratio; LSPS, LS spleen-diameter-to-platelet-ratio score; PH risk score, portal hypertension risk score; n, number of patients; P, prevalence; AUC, areas under the receiver operating characteristic curve; PPV, positive predictive value; NPV, negative predictive value; LR+, positive diagnostic likelihood ratio; LR−, negative diagnostic likelihood ratio
  3. *P < 0.05; **P < 0.001; ***P < 0.0001