Skip to main content

Table 3 Univariable analysis and multivariable analysis for PFS

From: Prognostic role of pretreatment 18F-FDG PET/CT and hematological parameters in relapsed/refractory Hodgkin lymphoma patients treated with immune checkpoint inhibitors and chemotherapy: a dual-center cohort study

Variable

Univariable analysis

Multivariable analysis

 

HR (95%CI)

P value

HR (95%CI)

P value

Sex

0.034 (0.000–17.840)

0.291

  

Age

0.995 (0.949–1.043)

0.829

  

Histology

1.058 (0.442–2.531)

0.899

  

Lugano classification

9.421 (2.070–32.784)

 < 0.001*

12.245(1.999–75.008)

0.007*

Staging

0.627 (0.538–2.797)

0.627

  

IPS

1.097 (0.714–1.686)

0.671

  

B symptoms

2.390 (0.514–11.112)

0.267

  

EBV

1.469 (0.441–4.892)

0.531

  

HBV

1.020 (0.219–4.743)

0.980

  

Bulky disease

0.472 (0.060–3.710)

0.475

  

SUVmax

1.012 (1.021–1.189)

0.013*

1.361(1.016–1.824)

0.039*

SUVmean

1.017 (0.774–1.336)

0.903

  

SUVpeak

1.009 (0.886–1.149)

0.892

  

MTV

0.996 (0.987–1.006)

0.472

  

TLG

0.998 (0.993–1.004)

0.569

  

SUVmaxwb

1.000 (0.998–1.002)

0.980

  

SUVmeanwb

1.000 (0.996–1.004)

0.961

  

SUVpeakwb

1.000 (0.997–1.002)

0.981

  

MTVwb

1.000 (0.999–1.001)

0.943

  

TLGwb

1.000 (0.999–1.000)

0.601

  

LDH, U/L

1.028 (1.012–1.045)

0.001*

1.064(1.020–1.111)

0.004*

Absolute platelet count, × 109/L

1.000 (0.994–1.006)

0.965

  

Absolute neutrophil count, × 109/L

1.179 (1.052–1.322)

0.005*

0.936(0.786–1.114)

0.457

Albumin levels, g/L

0.898 (0.802–1.006)

0.062

  

dNLR

0.882 (0.656–1.186)

0.407

  
  1. HR hazard ratio; 95%CI 95% confidence interval; IPS international prognostic score; EBV Epstein-Barr virus; HBV hepatitis B virus; SUVmax maximum standardized uptake value; SUVmean mean standardized uptake value; SUVpeak peak standardized uptake value; MTV metabolic tumor volume; TLG total lesion glycolysis; SUVmaxwb whole-body maximum standardized uptake value; SUVmeanwb whole-body mean standardized uptake value; SUVpeakwb whole-body peak standardized uptake value; MTVwb whole-body metabolic tumor volume; TLGwb whole-body total lesion glycolysis; LDH lactate dehydrogenase; dNLR derived neutrophil-to-lymphocyte ratio, defined as absolute neutrophil count/[white blood cell concentration − absolute neutrophil count];*P < 0.05