Table 2 Comparison of CEUS characteristics in nodules with different tumor size
From: Value of CEUS features in diagnosing thyroid nodules with halo sign on B-mode ultrasound
Indicator | ≤ 10 mm | p | > 10 mm | p | ||
|---|---|---|---|---|---|---|
Benign | Malignant | Benign | Malignant | |||
Wash-in | 0.736* | 0.161* | ||||
Earlier | 0 (0.0%) | 0 (0.0%) | 7 (31.8%) | 1 (11.1%) | ||
Meantime | 15 (71.4%) | 17 (77.3%) | 15 (68.2%) | 7 (77.8%) | ||
Later | 6 (28.6%) | 5 (22.7%) | 0 (0.0%) | 1 (11.1%) | ||
Intensity | 0.124* | 0.365* | ||||
Hypo-enhancement | 2 (9.5%) | 8 (36.4%) | 0 (0.0%) | 1 (11.1%) | ||
Iso-enhancement | 14 (66.7%) | 10 (45.5%) | 13 (59.1%) | 4 (44.4%) | ||
Hyper-enhancement | 5 (23.8%) | 4 (18.2%) | 9 (40.9%) | 4 (44.4%) | ||
Homogeneity | 1.000* | 0.063* | ||||
Homogeneity | 19 (90.5%) | 19 (86.4%) | 21 (95.5%) | 6 (66.7%) | ||
Heterogeneity | 2 (9.5%) | 3 (13.6%) | 1 (4.5%) | 3 (33.3%) | ||
Enhanced defect | 0.185* | 0.826* | ||||
Without | 17 (81.0%) | 21 (95.5%) | 12 (54.5%) | 6 (66.7%) | ||
With | 4 (19.0%) | 1 (4.5%) | 10 (45.5%) | 3 (33.3%) | ||
Enhanced pattern | 1.000* | 0.290* | ||||
Entire | 18 (85.7%) | 19 (86.4%) | 22 (100.0%) | 8 (88.9%) | ||
Centripetal | 1 (4.8%) | 2 (9.1%) | 0 (0.0%) | 0 (0.0%) | ||
Eccentrical | 2 (9.5%) | 1 (4.5%) | 0 (0.0%) | 1 (11.1%) | ||
Enhancing ring | 0.763* | 0.004* | ||||
Without | 9 (42.9%) | 11 (50.0%) | 9 (40.9%) | 3 (33.3%) | 0.221# | |
High | 1 (4.8%) | 0 (0.0%) | 10 (15.5%) | 0 (0.0%) | 0.003# | |
Low | 11 (52.4%) | 11 (50.0%) | 3 (13.6%) | 6 (66.7%) | 0.087# | |
Wash out | 0.656* | 0.287* | ||||
Earlier | 6 (28.6%) | 4 (18.2%) | 4 (18.2%) | 4 (44.4%) | ||
Later | 15 (71.4%) | 18 (81.8%) | 18 (81.8%) | 5 (55.6%) | ||