Table 1 Comparisons of demographics, clinical characteristics, and imaging findings between patients with PML, PCNSL, and GBM

Age (years) ± SD

52.3 ± 6.1

74.4 ± 5.8

65.0 ± 15.2

N.S

Male:female

2:2

3:4

6:5

N.S

Mean MTR_asym ± SD (lesion)

0.005 ± 0.005

0.025 ± 0.005

0.025 ± 0.009

0.012

Mean MTR_asym ± SD (normal-appearing tissue)

0.003 ± 0.002

0.003 ± 0.002

0.004 ± 0.002

0.389

T1 low intensity

2 (50%)

3 (42.9%)

6 (54.5%)

0.890

T2 hyperintensity

4 (100%)

6 (85.7%)

10 (90.9%)

0.730

Tumor location (above the tentorium)

3 (75%)

6 (85.7%)

11 (100%)

0.279

Multiple lesions

3 (75%)

4 (57.1%)

7 (63.6%)

0.839

Contralateral lesions

3 (75%)

3 (42.9%)

4 (36.4%)

0.408

Mass effect

0 (0%)

7 (100%)

11 (100%)

< 0.001

Enhancement

0 (0%)

7 (100%)

11 (100%)

< 0.001

Poor enhancement area

0 (0%)

0 (0%)

10 (90.9%)

< 0.001

Edema around the lesion

0 (0%)

7 (100%)

10 (90.9%)

< 0.001

3D ASL hyperintensity

0 (0%)

3 (42.9%)

9 (81.8%)

0.014