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Table 5 Characterization of focal lesion (32 HCC and 122 non-HCC) according to size

From: Prospective evaluation of low-dose multiphase hepatic computed tomography for detecting and characterizing hepatocellular carcinoma in patients with chronic liver disease

 

SDCT

Sensitivity

Specificity

PPV

NPV

Accuracy

 < 20 mm

 R1

85.2 (23/27)

100 (117/117)

100 (23/23)

96.7 (117/121)

97.2 (140/144)

 R2

85.2 (23/27)

100 (117/117)

100 (23/23)

96.7 (117/121)

97.2 (140/144)

 At least one

88.9 (24/27)

100 (117/117)

100 (24/24)

97.5 (117/120)

97.9 (141/144)

 > 20 mm

 R1

100 (5/5)

100 (5/5)

100 (5/5)

100 (5/5)

100 (10/10)

 R2

100 (5/5)

100 (5/5)

100 (5/5)

100 (5/5)

100 (10/10)

 At least one

100 (5/5)

100 (5/5)

100 (5/5)

100 (5/5)

100 (10/10)

Total

 R1

87.5 (28/32)

100 (122/122)

100 (28/28)

96.8 (122/126)

97.4 (150/154)

 R2

87.5 (28/32)

100 (122/122)

100 (28/28)

96.8 (122/126)

97.4 (150/154)

 At least one (95% C.I)

90.6 (29/32)

(75.0–98.0)

100 (122/122)

(97.0–100)

100 (29/29)

97.6 (122/125)

(93.3–99.2)

98.1 (151/154)

(94.4–99.6)

 

LDCT

Sensitivity

Specificity

PPV

NPV

Accuracy

 < 20 mm

 R1

74.1 (20/27)

100 (117/117)

100 (20/20)

94.4 (117/124)

95.1 (137/144)

 R2

74.1 (20/27)

100 (117/117)

100 (20/20)

94.4 (117/124)

95.1 (137/144)

 At least one

77.8 (21/27)

100 (117/117)

100 (21/21)

95.1 (117/123)

95.8 (138/144)

 > 20 mm

 R1

100 (5/5)

100 (5/5)

100 (5/5)

100 (5/5)

100 (10/10)

 R2

100 (5/5)

100 (5/5)

100 (5/5)

100 (5/5)

100 (10/10)

 At least one

100 (5/5)

100 (5/5)

100 (5/5)

100 (5/5)

100 (10/10)

Total

 R1

78.1 (25/32)

100 (122/122)

100 (25/25)

94.6 (122/129)

95.5 (147/154)

 R2

78.1 (25/32)

100 (122/122)

100 (25/25)

94.6 (122/129)

95.5 (147/154)

 At least one (95% C.I)

81.3 (26/32)

(63.6–92.8)

100 (122/122)

(97.0–100)

100 (26/26)

95.3 (122/128)

(90.8–97.7)

96.1 (148/154)

(91.7–98.6)

 

ULDCT

Sensitivity

Specificity

PPV

NPV

Accuracy

 < 20 mm

 R1

48.1 (13/27)

98.3 (115/117)

86.7 (13/15)

89.1 (115/129)

88.9 (128/144)

 R2

40.7 (11/27)

100 (117/117)

100 (11/11)

88.0 (117/133)

88.9 (128/144)

 At least one

51.9 (14/27)

98.3 (115/117)

87.5 (14/16)

89.8 (115/128)

89.6 (129/144)

 > 20 mm

 R1

80 (4/5)

100 (5/5)

100 (4/4)

100 (5/6)

90.0 (9/10)

 R2

80 (4/5)

100 (5/5)

100 (4/4)

100 (5/6)

90.0 (9/10)

 At least one

80 (4/5)

100 (5/5)

100 (4/4)

100 (5/6)

90.0 (9/10)

Total

 R1

53.1 (17/32)

98.4 (120/122)

89.5 (17/19)

89.7 (120/135)

89.0 (137/154)

 R2

46.9 (15/32)

100 (122/122)

100 (15/15)

88.4 (122/139)

89.0 (137/154)

 At least one (95% C.I)

56.2 (18/32)

(37.7–73.6)

98.4 (120/122)

(94.2–99.8)

90.0 (18/20)

(68.8–97.3)

89.6 (120/134)

(85.3–92.7)

89.6 (138/154)

(83.7–93.9)

  1. Values are in percentage and the fraction noted in the parenthesis indicates the number of positive lesions over the total lesions. At least one indicates the positive lesions detected or diagnosed either by reviewer 1 or 2
  2. SDCT standard-dose CT, LDCT low-dose CT, ULDCT ultra-low-dose CT, R1 Reader 1, R2 Reader2, PPV positive predictive value, NPV negative predictive value, CI confidence interval
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BMC Medical Imaging

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