Table 2 Comparison responder (RECIST 1.1 PR at 6 week CT) and non-responder (SD or PD at 6 week CT)
|  | Responders* (n = 27) | Non-responders+ (n = 71) | P-value× |
|---|---|---|---|
General features | |||
Sum of diameter CT [cm] | 7.7 ± 4.6 | 8.4 ± 3.9 | 0.44 |
Mean PFS ± SD [days] | 401 ± 211 | 317 ± 230 | 0.10 |
Mean OS ± SD [days] | 706 ± 320 | 508 ± 293 | 0.004 |
Pre-therapeutic MRI | |||
40 s rel. uptake [%] | 33.7 ± 15.6 | 28.4 ± 17.9 | 0.18 |
Slope 0–40 s [*10] | 9.4 ± 4.7 | 7.9 ± 4.9 | 0.19 |
70 s rel. uptake [%] | 49.0 ± 17.9 | 35.9 ± 25.6 | 0.02 |
Slope 0–70 s [*10] | 7.7 ± 2.4 | 5.6 ± 3.6 | 0.006 |
Max. uptake [SI] | 171 ± 24 | 162 ± 32 | 0.22 |
AUC [SI/250 s] | 4029 ± 551 | 3849 ± 731 | 0.24 |
Post-therapeutic MRI | |||
40 s rel. uptake [%] | 33.4 ± 12.0 | 25.3 ± 17.1 | 0.03 |
Slope 0–40 s [*10] | 9.7 ± 3.7 | 7.1 ± 4.6 | 0.01 |
70 s rel. uptake [%] | 47.3 ± 22.4 | 32.4 ± 24.1 | 0.007 |
Slope 0–70 s [*10] | 7.7 ± 3.2 | 5.0 ± 3.3 | < 0.001 |
Max. uptake [SI] | 182 ± 22 | 162 ± 25 | < 0.001 |
AUC [SI/250 s] | 4264 ± 509 | 3814 ± 610 | 0.001 |
Difference MRI pre-MRI post therapy | |||
Area difference MR1-MR2 [cm2] | 3.1 ± 4.1 | 0.6 ± 2.5 | < 0.001 |
Δ 40 s rel. uptake [%] | 0.3 ± 13.3 | 2.7 ± 15.8 | 0.49 |
Δ Slope 0–40 s [*10] | – 0.4 ± 3.4 | 0.7 ± 4.2 | 0.24 |
Δ 70 s rel. uptake [%] | 2.7 ± 22.1 | 2.7 ± 21.1 | 0.99 |
Δ Slope 0–70 s [*10] | 0.0 ± 2.8 | 0.5 ± 3.0 | 0.52 |
Δ Max. uptake [SI] | – 9 ± 22 | 0 ± 20 | 0.05 |
Δ AUC [SI/250 s] | – 184 ± 370 | 29 ± 474 | 0.04 |