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Table 2 Clinical factors predicting OS in patients with residual nasopharyngeal carcinoma after IMRT in the training cohort

From: Development and validation of an MRI-based radiomic model for predicting overall survival in nasopharyngeal carcinoma patients with local residual tumors after intensity-modulated radiotherapy

Characteristics

Value

Univariate analysis

Multivariate analysis

HR (95% CI)

P value

HR (95% CI)

P value

Age (years)

45.9ā€‰Ā±ā€‰11.6

1.042 (1.014ā€“ 1.071)

0.003a

Ā Ā 

ā€‰ā‰„ā€‰60

20 (11.6%)

3.480 (1.738ā€“6.966)

ā€‰<ā€‰0.001a

2.829 (1.394ā€“5.741)

0.004b

ā€‰<ā€‰60

153 (88.4%)

Reference

Ā 

Reference

Ā 

Gender

Male

127 (73.4%)

2.884 (1.132ā€“7.352)

0.027a

2.586 (1.005ā€“6.654)

0.049b

Female

46 (26.6%)

Reference

Ā 

Reference

Ā 

T category

T1

5 (2.9%)

ā€‰<ā€‰0.001 (<ā€‰0.001ā€“NA)

0.972a

Ā Ā 

T2

10 (5.8%)

1.217 (0.366ā€“4.049)

0.749a

Ā Ā 

T3

66 (38.2%)

0.788 (0.408ā€“1.524)

0.480a

Ā Ā 

T4

92 (53.2%)

Reference

Ā Ā Ā 

N category

N0

15 (8.7%)

Reference

Ā Ā Ā 

N1

71 (41.0%)

5.580 (0.749ā€“41.555)

0.093a

Ā Ā 

N2

68 (39.3%)

3.519 (0.459ā€“26.997)

0.226a

Ā Ā 

N3

19 (11.0%)

6.295 (0.756ā€“52.422)

0.089a

Ā Ā 

Stage

Ā Ā 

0.202a

Ā Ā 

I

1 (0.6%)

ā€‰<ā€‰0.001 (<ā€‰0.001ā€“NA)

0.980a

Ā Ā 

II

10 (5.8%)

1.162 (0.352ā€“3.836)

0.806a

Ā Ā 

III

62 (35.8%)

0.611 (0.303ā€“1.233)

0.169a

Ā Ā 

IV

100 (57.8%)

Reference

Ā Ā Ā 

NLR

2.5 (1.9ā€“3.4)

1.114 (0.918ā€“1.352)

0.275a

Ā Ā 

ā€‰ā‰¤ā€‰2.9

107 (61.8%)

1.290 (0.668ā€“2.491)

0.445a

Ā Ā 

ā€‰>ā€‰2.9

66 (38.2%)

Reference

Ā Ā Ā 

Hemoglobin (g/L)

135.1ā€‰Ā±ā€‰15.2

1.009 (0.987ā€“1.031)

0.434a

Ā Ā 

ā€‰ā‰¤ā€‰132.4

68 (39.3%)

Reference

0.220a

Ā Ā 

ā€‰>ā€‰132.4

105 (60.7%)

1.510 (0.781ā€“2.918)

Ā Ā Ā 

Albumin (g/L)

43.8ā€‰Ā±ā€‰3.5

0.993 (0.906ā€“1.089)

0.886a

Ā Ā 

ā€‰ā‰¤ā€‰40.5

35 (20.2%)

2.244 (1.175ā€“4.285)

0.012a

Reference

Ā 

ā€‰>ā€‰40.5

138 (79.8%)

Reference

Ā 

0.477 (0.248ā€“0.917)

0.026b

Induction chemotherapy

Yes

56 (32.4%)

1.176 (0.623ā€“2.221)

0.617a

Ā Ā 

No

117 (67.6%)

Reference

Ā Ā Ā 

Concurrent chemotherapy

Yes

163 (94.2%)

0.607 (0.216ā€“1.704)

0.343a

Ā Ā 

No

10 (5.8%)

Reference

Ā Ā Ā 

Adjuvant chemotherapy

Yes

93 (53.8%)

1.015 (0.549ā€“1.876)

0.962a

Ā Ā 

No

80 (46.2%)

Reference

Ā Ā Ā 
  1. NLR neutrophil to lymphocyte ratio
  2. The cutoffs for NLR, hemoglobin, and albumin were determined based on maximally selected test statistics
  3. aP values tested with the univariate Cox model
  4. bP values tested with the multivariate Cox model