Fig. 2

A 70-year-old female patient with bloody nipple discharge for 3 months. Comparison of ultrasound sonogram and fiberoptic ductoscopy of invasive ductal carcinoma of the breast was performed. Conventional two-dimensional ultrasound A showing a 2.2 cm × 1.2 cm cystic solid nodule (long arrow) in the gland layer approximately about 3 cm from the nipple in the 10 o'clock direction in the left breast. The nodule morphology was irregular, exhibiting “crab feet”-like margins. Adjacent duct dilation (short arrow) was observed, which extended to the nipple, showing poor intraductal sound penetration; CDFI (B) revealing punctate and short bar-like blood flow signals in the space-occupying lesion. FDS (C) revealing an irregular intraductal neoplasm completely obstructing the lumen, which bled easily when touched. Adjacent ductal walls were stiff with poor elasticity. The rear lumen was inaccessible