Table 2 Comparison of clinical and MRI imaging features of phenotype status for each molecular biomarker

Age

57.0 [43.8;64.5]

44.0 [38.0;51.5]

0.003

57.0 [42.5;64.5]

45.5 [39.0;57.8]

0.054

46.5 [37.0;57.0]

52.0 [43.0;63.5]

0.074

53.0 [39.0;62.2]

45.0 [42.0;58.0]

0.294

Grade:

 < 0.001

0.11

0.046

0.269

Grade I

2 (4.76%)

0 (0.00%)

2 (6.45%)

0 (0.00%)

2 (5.88%)

0 (0.00%)

2 (3.85%)

0 (0.00%)

Grade II

9 (21.4%)

17 (43.6%)

9 (29.0%)

17 (34.0%)

15 (44.1%)

11 (23.4%)

17 (32.7%)

9 (31.0%)

Grade III

10 (23.8%)

19 (48.7%)

8 (25.8%)

21 (42.0%)

10 (29.4%)

19 (40.4%)

15 (28.8%)

14 (48.3%)

Grade IV

21 (50.0%)

3 (7.69%)

12 (38.7%)

12 (24.0%)

7 (20.6%)

17 (36.2%)

18 (34.6%)

6 (20.7%)

Frontal lobe:

 < 0.001

0.007

0.777

0.163

Non-involving

22 (52.4%)

4 (10.3%)

16 (51.6%)

10 (20.0%)

12 (35.3%)

14 (29.8%)

20 (38.5%)

6 (20.7%)

Involving

20 (47.6%)

35 (89.7%)

15 (48.4%)

40 (80.0%)

22 (64.7%)

33 (70.2%)

32 (61.5%)

23 (79.3%)

Parietal lobe:

0.001

0.104

0.644

0.087

Non-involving

28 (66.7%)

38 (97.4%)

22 (71.0%)

44 (88.0%)

29 (85.3%)

37 (78.7%)

39 (75.0%)

27 (93.1%)

Involving

14 (33.3%)

1 (2.56%)

9 (29.0%)

6 (12.0%)

5 (14.7%)

10 (21.3%)

13 (25.0%)

2 (6.90%)

Involving cortex matter:

0.001

0.027

0.202

0.087

Non-involving

14 (33.3%)

1 (2.56%)

10 (32.3%)

5 (10.0%)

9 (26.5%)

6 (12.8%)

13 (25.0%)

2 (6.90%)

Involving

28 (66.7%)

38 (97.4%)

21 (67.7%)

45 (90.0%)

25 (73.5%)

41 (87.2%)

39 (75.0%)

27 (93.1%)

Involving pial matter:

0.22

0.316

0.01

0.399

Non-involving

24 (57.1%)

16 (41.0%)

18 (58.1%)

22 (44.0%)

23 (67.6%)

17 (36.2%)

28 (53.8%)

12 (41.4%)

Involving

18 (42.9%)

23 (59.0%)

13 (41.9%)

28 (56.0%)

11 (32.4%)

30 (63.8%)

24 (46.2%)

17 (58.6%)

Border:

0.056

0.007

1

0.163

clear

18 (42.9%)

8 (20.5%)

16 (51.6%)

10 (20.0%)

11 (32.4%)

15 (31.9%)

20 (38.5%)

6 (20.7%)

Non-clear

24 (57.1%)

31 (79.5%)

15 (48.4%)

40 (80.0%)

23 (67.6%)

32 (68.1%)

32 (61.5%)

23 (79.3%)

Oedema degree:

0.008

0.011

0.419

0.752

 < 1.6 cm

18 (42.9%)

29 (74.4%)

12 (38.7%)

35 (70.0%)

22 (64.7%)

25 (53.2%)

29 (55.8%)

18 (62.1%)

 > 1.6 cm

24 (57.1%)

10 (25.6%)

19 (61.3%)

15 (30.0%)

12 (35.3%)

22 (46.8%)

23 (44.2%)

11 (37.9%)

Enhancemengt_style:

 < 0.001

0.04

0.196

0.013

No

4 (9.52%)

17 (43.6%)

4 (12.9%)

17 (34.0%)

12 (35.3%)

9 (19.1%)

13 (25.0%)

8 (27.6%)

Ring-enhancement

18 (42.9%)

1 (2.56%)

12 (38.7%)

7 (14.0%)

5 (14.7%)

14 (29.8%)

18 (34.6%)

1 (3.45%)

Nodular-enhancement

5 (11.9%)

11 (28.2%)

6 (19.4%)

10 (20.0%)

8 (23.5%)

8 (17.0%)

8 (15.4%)

8 (27.6%)

Irregular-enhancement

15 (35.7%)

10 (25.6%)

9 (29.0%)

16 (32.0%)

9 (26.5%)

16 (34.0%)

13 (25.0%)

12 (41.4%)

Enhancement_degree:

 < 0.001

0.006

0.202

0.095

No

4 (9.52%)

17 (43.5%)

4(12.9%)

17 (34.0%)

12 (35.3%)

9 (19.1%)

13 (25.0%)

8 (27.6%)

Slight

4 (9.52%)

11 (28.2%)

3 (9.67%)

12 (24.0%)

7 (20.5%)

8 (17.0%)

6 (11.5%)

9 (31.0%)

Obvious

34 (81.0%)

11 (28.2%)

24 (77.4%)

21 (42.0%)

15 (44.1%)

30 (63.8%)

33 (63.5%)

12 (41.4%)

Signal characteristics:

0.038

0.19

1

1

Homogenous

2 (4.76%)

9 (23.1%)

2 (6.45%)

9 (18.0%)

5 (14.7%)

6 (12.8%)

7 (13.5%)

4 (13.8%)

Heterogenous

40 (95.2%)

30 (76.9%)

29 (93.5%)

41 (82.0%)

29 (85.3%)

41 (87.2%)

45 (86.5%)

25 (86.2%)