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Table 4 Comparison of ADC histogram parameters between stage IA EC and BELs

From: Whole-lesion apparent diffusion coefficient (ADC) histogram as a quantitative biomarker to preoperatively differentiate stage IA endometrial carcinoma from benign endometrial lesions

Histogram parameters

BELs (n = 106) *

ECs (n = 126) *

p value

Intra-observer ICC (95%CI)

Inter-observer ICC (95%CI)

Volume (× 103 mm3)

6.076 (2.511, 10.477)

4.803 (2.533, 10.283)

0.581

0.985 (0.976–0.991)

0.972 (0.956–0.987)

ADC10th (× 10−3 mm2/s)

1.129 (1.047, 1.236)

0.815 (0.722, 0.884)

< 0.001

0.997 (0.996–0.998)

0.996 (0.995–0.998)

ADC90th (× 10−3 mm2/s)

1.521 (1.401,1.775)

1.189 (1.081, 1.312)

< 0.001

0.994 (0.993–0.996)

0.992 (0.990–0.995)

ADCmin (× 10−3 mm2/s)

0.945 ± 0.164

0.697 ± 0.149

< 0.001

0.965 (0.929–0.983)

0.953 (0.902–0.978)

ADCmax (× 10−3 mm2/s)

1.788 (1.549, 2.089)

1.511 (1.349, 1.704)

< 0.001

0.982 (0.964–0.992)

0.978 (0.955–0.990)

ADCmean (× 10−3 mm2/s)

1.314 (1.219, 1.492)

0.989 (0.885, 1.083)

< 0.001

0.998 (0.996–0.998)

0.997 (0.995–0.998)

ADCmedian (× 10−3 mm2/s)

1.315 (1.206, 1.458)

0.970 (0.872, 1.057)

< 0.001

0.998 (0.996–0.999)

0.996 (0.995–0.998)

IQR (× 10−3 mm2/s)

0.212 (0.167, 0.277)

0.191 (0.155, 0.237)

0.014

0.974 (0.946–0.988)

0.965 (0.927–0.983)

Range (× 10−3 mm2/s)

0.854 (0.655, 1.115)

0.802 (0.629, 1.027)

0.164

0.974 (0.946–0.987)

0.976 (0.950–0.989)

MAD (× 10–3)

0.128 (0.107, 0.166)

0.112 (0.098, 0.144)

0.013

0.992 (0.982–0.996)

0.988 (0.976–0.994)

rMAD (× 10–3)

0.088 (0.074, 0.115)

0.079 (0.064, 0.099)

0.007

0.990 (0.978–0.995)

0.985 (0.968–0.993)

RMS (× 10–3)

1.324 (1.229, 1.507)

1.003 (0.896, 1.100)

< 0.001

0.998 (0.996–0.998)

0.997 (0.996–0.998)

Energy (× 10–3)

0.781 (0.364, 1.599)

0.354 (0.195, 0.720)

< 0.001

0.997 (0.992–0.998)

0.996 (0.994–0.999)

Total energy (× 10–3)

11.134(4.152, 19.947)

4.926 (2.454, 10.009)

< 0.001

0.997 (0.994–0.999)

0.997 (0.994–0.999)

Entropy (× 10–6)

4.225 ± 0.582

4.038 ± 0.425

0.007

0.994 (0.987–0.997)

0.965 (0.927–0.983)

Skewness (× 10–6)

0.215 ± 0.522

0.744 ± 0.603

< 0.001

0.980 (0.959–0.990)

0.970 (0.935–0.986)

Kurtosis (× 10–6)

2.960 (2.438, 3.345)

3.377 (2.743, 4.451)

< 0.001

0.955 (0.906–0.979)

0.926 (0.891–0.954)

Variance (× 10–6)

0.027(0.017, 0.042)

0.022 (0.015, 0.034)

0.030

0.989 (0.977–0.995)

0.987 (0.972–0.994)

Uniformity (× 10–6)

0.065(0.049, 0.078)

0.072 (0.059, 0.087)

0.002

0.984 (0.967–0.992)

0.982 (0.961–0.991)

  1. IQR, interquartile range; MAD, mean absolute deviation; rMAD, robust mean absolute deviation; RMS, root mean squared; ICC, intraclass correlation coefficients
  2. *Data are mean ± standard deviation (normal distribution) or median and interquartile range (non-normal distribution), evaluated using the Kolmogorov–Smirnov test
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BMC Medical Imaging

ISSN: 1471-2342

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