Automated brain volumetric measures with AccuBrain: version comparison in accuracy, reproducibility and application for diagnosis

Zhao, Lei; Luo, Yishan; Mok, Vincent; Shi, Lin

doi:10.1186/s12880-022-00841-2

Table 3 ICC for intra-scanner reproducibility regarding absolute volumes and AD-RAI

From: Automated brain volumetric measures with AccuBrain: version comparison in accuracy, reproducibility and application for diagnosis

Absolute volumes	NC (n = 20)		AD (n = 42)
Absolute volumes	AccuBrain IV2.0	AccuBrain IV1.2	AccuBrain IV2.0	AccuBrain IV1.2
Intracranial volume	0.990 (0.979, 0.996)	0.995 (0.988, 0.998)	0.990 (0.983, 0.994)	0.996 (0.993, 0.997)
Brain parenchyma	0.99 (0.98, 1.00)	0.98 (0.96, 0.99)	0.99 (0.98, 1.00)	0.99 (0.98, 1.00)
White matter	0.97 (0.95, 0.99)	0.96 (0.92, 0.98)	0.97 (0.95, 0.98)	0.96 (0.94, 0.98)
Gray matter	0.99 (0.97, 0.99)	0.98 (0.96, 0.99)	0.97 (0.95, 0.98)	0.98 (0.97, 0.99)
Hippocampus L	0.98 (0.96, 0.99)*	0.91 (0.83, 0.96)	0.99 (0.99, 1.00)	0.99 (0.98, 0.99)
Hippocampus R	0.99 (0.97, 0.99)*	0.90 (0.80, 0.95)	0.992 (0.987, 0.996)*	0.977 (0.961, 0.987)
Amygdala L	0.95 (0.90, 0.98)	0.94 (0.88, 0.97)	0.98 (0.96, 0.99)	0.98 (0.97, 0.99)
Amygdala R	0.93 (0.87, 0.97)	0.94 (0.88, 0.97)	0.976 (0.961, 0.986)	0.991 (0.984, 0.995)*
Lateral ventricle L	0.999 (0.999, 1.000)	0.999 (0.998, 1.000)	0.999 (0.998, 0.999)	0.999 (0.999, 0.999)
Lateral ventricle R	0.999 (0.997, 0.999)	0.997 (0.995, 0.999)	0.999 (0.998, 0.999)	0.999 (0.998, 0.999)
Inf Lat Vent L	0.991 (0.981, 0.996)	0.976 (0.951, 0.990)	0.995 (0.992, 0.997)	0.995 (0.992, 0.997)
Inf Lat Vent R	0.976 (0.951, 0.990)	0.985 (0.969, 0.994)	0.993 (0.988, 0.996)	0.995 (0.991, 0.997)
Thalamus L	0.98 (0.96, 0.99)	0.98 (0.95, 0.99)	0.98 (0.97, 0.99)	0.98 (0.97, 0.99)
Thalamus R	0.98 (0.97, 0.99)	0.98 (0.96, 0.99)	0.98 (0.97, 0.99)	0.98 (0.97, 0.99)
Caudate L	0.99 (0.97, 0.99)	0.99 (0.98, 1.00)	0.99 (0.98, 0.99)	0.98 (0.97, 0.99)
Caudate R	0.99 (0.98, 1.00)	0.99 (0.98, 1.00)	0.98 (0.97, 0.99)	0.99 (0.98, 0.99)
Putamen L	0.98 (0.96, 0.99)	0.99 (0.97, 0.99)	0.98 (0.97, 0.99)	0.98 (0.97, 0.99)
Putamen R	0.96 (0.93, 0.99)	0.96 (0.92, 0.98)	0.97 (0.95, 0.98)	0.97 (0.96, 0.98)
Pallidum L	0.96 (0.92, 0.98)	0.95 (0.90, 0.98)	0.96 (0.93, 0.98)	0.97 (0.94, 0.98)
Pallidum R	0.95 (0.91, 0.98)	0.96 (0.92, 0.98)	0.98 (0.97, 0.99)	0.97 (0.95, 0.98)
Midbrain	0.98 (0.96, 0.99)	0.97 (0.94, 0.99)	0.99 (0.99, 1.00)	0.99 (0.99, 1.00)
Pons	0.99 (0.98, 1.00)	0.99 (0.98, 1.00)	0.995 (0.991, 0.997)	0.996 (0.993, 0.998)
Cerebellum	0.99 (0.98, 1.00)	0.99 (0.98, 1.00)	0.99 (0.99, 1.00)	0.99 (0.99, 1.00)
AD-RAI	0.983 (0.965,0.993)	0.984 (0.967,0.993)	0.982 (0.970, 0.990)	0.979 (0.965, 0.988)

The ICC values were displayed in terms of point estimate and 95% CI with lower and upper limits
*Significantly different based on point estimate of AccuBrain IV2.0 not lying within the confidence interval (CI) of AccuBrain IV1.2, where the point estimate of ICC for this version (labeled with *) is larger than the upper limit of 95% CI of the other version by ≥ 0.005

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