Table 1 Overview of studies evaluating prognostic role of variable PET-CT parameters in multiple myeloma

Bartel et al. [15]

Prospective

239

At diagnosis and before autologous SCT

nFL > 3 (OS and EFS), SUVmax > 3.9 (EFS*), EMD-positivity (OS* and EFS*)

Zamagni et al. [8]

Prospective

192

At diagnosis

SUVmax > 4.2 (OS and PFS), EMD-positivity (OS and PFS), nFLs > 3 (PFS*)

Fonti et al. [21]

Retrospective

47

At diagnosis, with subpopulation in relapse

MTV (OS and PFS)

Usmani et al. [11]

Prospective

302

At diagnosis and at induction day 7

nFL > 3 on day 7 (OS and PFS)

Zamagni et al. [9]

Retrospective

282

After first line

SUVmax > 4.2 (PFS and OS), nFL > 3 (OS* and PFS*), EMD-positivity (OS* and PFS*)

Patriarca et al. [10]

Retrospective

67

Before allogeneic SCT

SUVmax > 4.2 (OS and PFS*), EMD-positivity (OS* and PFS), nFL > 1 (OS* and PFS*),

Beksac et al. [12]

Prospective

139

Before and after autologous SCT

SUVmax > 3.35 (OS), SUVmax > 4.2 (PFS)

Moreau et al. [22]

Prospective

134

After first line compared to PET at diagnosis

PET-positive versus PET-normalization (PFS and OS)

Davies et al. [14]

Retrospective (based on population of TT4-6 trials)

596

At diagnosis, during and after induction

nFL > 3 (OS, PFS) at diagnosis. Suppression of FL-signal beneficial

Wang et al. [16]

Retrospective

123

At diagnosis

SUVmax > 5.7 (OS*), EMD-positivity (OS and PFS)

Moon et al. [17]

Retrospective

76

At diagnosis

nFL > 3 (OS and PFS), EMD-positivity (OS and PFS)

Fonti et al. [23]

Retrospective

47

At diagnosis

MVT (OS and PFS), TLG (OS* and PFS*), SUVmax (OS*), nFL (OS* and PFS*)

Lapa et al. [18]

Retrospective

37

At relapse

nFL > 10 (TTP and OS), EMD (TTP and OS), SUVmax (ROC) > 18.5 (TTP)

Jamet et al. [19]

Retrospective

40

At relapse

nFL (appendicular skeleton) > 6 (OS, PFS), TLG (OS), SUVmax (ROC) > 15.9 (PFS), nFLs > 13 (PFS*)