Table 4 HER2 and clinical and ultrasound features in Group III from the training set
Clinical and ultrasound features | Group III | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|
HER2− (ER−, PR−) (N = 194) | HER2+ (ER−, PR−) (N = 138) | X2 Value | P value | OR (95%CI) | P value | |
Age (year) | Â | Â | 2.161 | 0.142 | Â | Â |
 ≤ 50 | 83 (42.8) | 48 (34.8) |  |  |  |  |
 > 50 | 111 (57.2) | 90 (65.2) |  |  |  |  |
Palpable ALN | Â | Â | 7.429 | 0.006* | Â | 0.001* |
 No | 149 (76.8) | 87 (63.0) |  |  | 1 |  |
 Yes | 45 (23.2) | 51 (37.0) |  |  | 2.319 (1.381–3.895) |  |
US ALN | Â | Â | 5.922 | 0.015* | Â | Â |
 No | 105 (54.1) | 56 (40.6) |  |  |  |  |
 Yes | 89 (45.9) | 82 (59.4) |  |  |  |  |
Breast cancer family history | Â | Â | 1.016 | 0.313 | Â | Â |
 No | 184 (94.8) | 134 (97.1) |  |  |  |  |
 Yes | 10 (5.2) | 4 (2.9) |  |  |  |  |
Menopause | Â | Â | 2.442 | 0.118 | Â | Â |
 No | 84 (43.3) | 48 (34.8) |  |  |  |  |
 Yes | 110 (56.7) | 90 (65.2) |  |  |  |  |
BMI (kg/m2) | Â | Â | 1.075 | 0.584 | Â | Â |
 < 18 | 3 (1.5) | 2 (1.4) |  |  |  |  |
 18–24 | 119 (61.4) | 77 (55.8) |  |  |  |  |
 > 24 | 72 (37.1) | 59 (42.8) |  |  |  |  |
Tumor size (mm) | Â | Â | 0.180 | 0.671 | Â | Â |
 ≤ 20 | 29 (14.9) | 23 (16.7) |  |  |  |  |
 > 20 | 165 (85.1) | 115 (83.3) |  |  |  |  |
Shape | Â | Â | 10.710 | 0.005* | Â | 0.015* |
 Oval | 28 (14.4) | 5 (3.6) |  |  | 1 |  |
 Round | 7 (3.6) | 7 (5.1) |  |  | 7.491 (1.715–32.724) | 0.007* |
 Irregular | 159 (82.0) | 126 (91.3) |  |  | 3.786 (1.369–10.470) | 0.010* |
Orientation | Â | Â | 0.035 | 0.851 | Â | Â |
 Parallel | 126 (64.9) | 91 (65.9) |  |  |  |  |
 Not parallel | 68 (35.1) | 47 (34.1) |  |  |  |  |
Margin | Â | Â | 0.032 | 0.859 | Â | Â |
 Circumscribed | 5 (2.6) | 4 (2.9) |  |  |  |  |
 Not circumscribed | 189 (97.4) | 134 (97.1) |  |  |  |  |
Boundary | Â | Â | 0.251 | 0.616 | Â | Â |
 Abrupt | 140 (72.2) | 103 (74.6) |  |  |  |  |
 Halo | 54 (27.8) | 35 (25.4) |  |  |  |  |
Echo pattern | Â | Â | 4.203 | 0.240 | Â | Â |
 Hypoechoic | 175 (90.2) | 129 (93.5) |  |  |  |  |
 Isoechoic | 2 (1.0) | 2 (1.4) |  |  |  |  |
 Complex | 15 (7.8) | 4 (2.9) |  |  |  |  |
 Hyperechoic | 2 (1.0) | 3 (2.2) |  |  |  |  |
Posterior acoustic features | Â | Â | 9.179 | 0.027* | Â | Â |
 No | 47 (24.2) | 35 (25.4) |  |  |  |  |
 Enhancement | 106 (54.7) | 56 (40.6) |  |  |  |  |
 Shadowing | 34 (17.5) | 42 (30.4) |  |  |  |  |
 Combined | 7 (3.6) | 5 (3.6) |  |  |  |  |
Calcifications |  |  | 24.579 |  < 0.001* |  |  < 0.001* |
 No | 111 (57.2) | 41 (29.7) |  |  | 1 |  |
 Yes | 83 (42.8) | 97 (70.3) |  |  | 3.346 (2.051–5.459) |  |
Vascular degree | Â | Â | 4.973 | 0.174 | Â | Â |
 0 | 27 (13.9) | 12 (8.7) |  |  |  |  |
 I | 25 (12.9) | 23 (16.7) |  |  |  |  |
 II | 86 (44.3) | 72 (52.2) |  |  |  |  |
 III | 56 (28.9) | 31 (22.4) |  |  |  |  |