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Table 3 PR and clinical and ultrasound features in Group II from the training set

From: Application of preoperative ultrasound features combined with clinical factors in predicting HER2-positive subtype (non-luminal) breast cancer

Clinical and ultrasound features

Group II

Univariate analysis

Multivariate analysis

PR− (ER+, HER2−)

(N = 62)

PR+ (ER+, HER2−)

(N = 636)

X2 Value

P value

OR (95%CI)

P value

Age (year)

  

7.747

0.005*

 

0.007*

 ≤ 50

18 (29.0)

302 (47.5)

  

2.204 (1.238–3.924)

 

 > 50

44 (71.0)

334 (52.5)

  

1

 

Palpable ALN

  

0.345

0.557

  

 No

51 (82.3)

541 (85.1)

    

 Yes

11 (17.7)

95 (14.9)

    

US ALN

  

1.431

0.232

  

 No

38 (61.3)

437 (68.7)

    

 Yes

24 (38.7)

199 (31.3)

    

Breast cancer family history

  

0.001

0.974

  

 No

60 (96.8)

615 (96.7)

    

 Yes

2 (3.2)

21 (3.3)

    

Menopause

  

6.158

0.013*

  

 No

20 (32.3)

310 (48.7)

    

 Yes

42 (67.7)

326 (51.3)

    

BMI (kg/m2)

  

1.391

0.499

  

 < 18

3 (4.8)

15 (2.4)

    

 18–24

33 (53.2)

351 (55.2)

    

 > 24

26 (42.0)

270 (42.4)

    

Tumor size (mm)

  

0.002

0.964

  

 ≤ 20

14 (22.6)

142 (22.3)

    

 > 20

48 (77.4)

494 (77.7)

    

Shape

  

1.664

0.435

  

 Oval

1 (1.6)

29 (4.6)

    

 Round

4 (6.5)

28 (4.4)

    

 Irregular

57 (91.9)

579 (91.0)

    

Orientation

  

0.853

0.356

  

 Parallel

34 (54.8)

387 (60.8)

    

 Not parallel

28 (45.2)

249 (39.2)

    

Margin

  

0.140

0.708

  

 Circumscribed

1 (1.6)

15 (2.4)

    

 Not circumscribed

61 (98.4)

621 (97.6)

    

Lesion boundary

  

0.007

0.934

  

 Abrupt

37 (59.7)

383 (60.2)

    

 Halo

25 (40.3)

253 (39.8)

    

Echo pattern

  

3.643

0.303

  

 Hypoechoic

59 (95.2)

554 (87.1)

    

 Isoechoic

1 (1.6)

28 (4.4)

    

 Complex

2 (3.2)

43 (6.8)

    

 Hyperechoic

0 (0.0)

11 (1.7)

    

Posterior acoustic features

     

0.039*

 No features

14 (22.6)

213 (33.5)

8.951

0.03*

1

 

 Enhancement

26 (41.9)

158 (24.8)

  

0.418 (0.211–0.830)

0.013*

 Shadowing

20 (32.3)

246 (38.7)

  

0.876 (0.430–1.785)

0.715

 Combined

2 (3.2)

19 (3.0)

  

0.453 (0.115–2.632)

0.453

Calcification

  

0.032

0.859

  

 No

33 (53.2)

331 (52.0)

    

 Yes

29 (46.8)

305 (48.0)

    

Vascular degree

  

0.960

0.811

  

 0

9 (14.5)

99 (15.6)

    

 I

9 (14.5)

110 (17.3)

    

 II

27 (43.6)

285 (44.8)

    

 III

17 (27.4)

142 (22.3)

    
  1. ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor-2, BMI body mass index, ALN axillary lymph node, US ultrasound