Adenocarcinoma in situ and minimally invasive adenocarcinoma in lungs of smokers: image feature differences from those in lungs of non-smokers

Table 3 Subgroup analysis based on unenhanced and contrast-enhanced CT

Unenhanced examination	Non-smoker	Smoker	p-value
Unenhanced examination	(n = 8)	(n = 9)	p-value
Longest diameter of the entire lesion (mm)
CT measurement	16.3 ± 4.1	17.1 ± 5.4	p = 0.888
Pathological measurement	15.0 ± 5.2	17.3 ± 8.1	p = 1.000
Longest diameter of solid/invasive component (mm)
CT measurement	2.3 ± 3.0	2.8 ± 2.6	p = 0.807
Pathological measurement	2.2 ± 1.7	2.0 ± 1.6	p = 0.799
Internal CT value (HU)
CT value of entire lesion	− 569 ± 43	− 603 ± 72	p = 0.265
CT value of ground-glass opacity	− 550 ± 82	− 623 ± 83	p = 0.093

Contrast-enhanced examination	Non-smoker	Smoker	p-value
Contrast-enhanced examination	(n = 19)	(n = 18)	p-value
Longest diameter of the entire lesion (mm)
CT measurement	13.9 ± 4.9	17.2 ± 3.3	p = 0.029^*
Pathological measurement	11.4 ± 3.7	15.7 ± 3.7	p < 0.001^*
Longest diameter of solid/invasive component (mm)
CT measurement	2.2 ± 2.6	2.2 ± 3.1	p = 0.834
Pathological measurement	2.3 ± 2.1	2.2 ± 1.8	p = 0.849
Internal CT value (HU)
CT value of entire lesion	− 523 ± 121	− 590 ± 82	p = 0.096
CT value of ground-glass opacity	− 550 ± 142	− 606 ± 116	p = 0.196

If the radiologist concluded that there was no solid component, the diameter of solid component was calculated as 0 mm. for pathological measurement, invasive component of AIS was calculated as 0 mm by definition
Values are shown as means ± standard deviations
HU Hounsfield unit
^*Significant difference

ISSN: 1471-2342