Table 3 Diagnostic performance for T1 relaxation time and ADC value in evaluating MVI-positive HCC
Parameters | AUC | Thresholds | Sensitivity | Specificity | Accuracy | +LR | -LR | PPV | NPV |
|---|---|---|---|---|---|---|---|---|---|
T1 relaxation time | |||||||||
Pre-contrast | 0.587 | 1138.4a | 78.9% | 44.7% | 58.5% | 1.4 | 0.5 | 49.2% | 75.8% |
95% CI | 0.481–0.688 | 62.7–90.4% | 313–58.5% | 48.6–68.5% | 1.1–1.9 | 0.2–0.9 | 36.1–62.3% | 57.7–88.9% | |
862.1b | 21.1% | 91.1% | 62.8% | 2.4 | 0.9 | 61.5% | 63.0% | ||
9.6–37.3% | 80.4–97.0% | 52.3–72.5% | 0.8–6.7 | 0.7–1.0 | 31.6–86.1% | 51.5–73.4% | |||
Postcontrast | 0.728 | 586.7a | 57.9% | 75.0% | 68.1% | 2.3 | 0.6 | 61.1% | 72.4% |
95% CI | 0.626–0.814 | 40.8–73.7% | 61.6–85.6% | 58.7–77.5% | 1.4–3.9 | 0.40–0.80 | 43.5–76.9% | 59.1–83.3% | |
679.4b | 34.2% | 91.1% | 68.1% | 3.8 | 0.7 | 72.2% | 67.1% | ||
19.6–51.4% | 80.4–97.0% | 58.7–77.5% | 1.5–9.9 | 0.6–0.9 | 46.5–90.3% | 55.4–77.5% | |||
Reduction rate | 0.824 | 44.9%a | 79.0% | 73.2% | 75.5% | 3.0 | 0.3 | 66.7% | 83.7% |
95% CI | 0.732–0.895 | 62.7–90.4% | 59.7–84.2% | 66.9–84.2% | 1.9–4.7 | 0.2–0.5 | 51.0–80.0% | 70.3–92.7% | |
38.0%b | 47.4% | 91.1% | 74.4% | 5.3 | 0.6 | 78.3% | 71.8% | ||
31.0–64.2% | 80.4–97.0% | 64.5–82.3% | 2.2–13.1 | 0.4–0.8 | 56.3–92.5% | 59.9–81.9% | |||
ADC | 0.690 | 1553.5a | 71.1% | 66.1% | 68.1% | 2.1 | 0.4 | 58.7% | 77.1% |
95% CI | 0.586–0.781 | 51.1–84.6% | 52.2–78.2% | 58.7–77.5% | 1.4–3.2 | 0.30–0.70 | 43.2–73.0% | 62.7–88.0% | |
1339.1b | 31.6% | 92.9% | 69.1% | 4.8 | 0.7 | 76.5% | 67.5% | ||
17.5–48.7% | 82.7–98.0% | 59.8–78.5% | 1.7–13.6 | 0.6–0.9 | 50.1–93.2% | 55.9–77.8% | |||
Reduction rate + ADC | 0.864d | 44.9% + 1553.5c | 60.6% | 91.8% | 80.9% | 7.4 | 0.4 | 80.0% | 81.2% |
95% CI | 0.776–0.952 | 42.2–76.6% | 81.2–96.9% | 72.9–88.9% | 3.1–17.9 | 0.3–0.7 | 58.7–92.4% | 69.6–89.2% | |