18F- FDG PET/CT-derived parameters predict clinical stage and prognosis of esophageal cancer

BMC Medical Imaging

Table 4 Cox regression analysis for disease-free survival (DFS)

Variable	Unadjusted HR	95%CI	P-value	Adjusted HR	95%CI	P-value
All patients
Active smoking	2.22	1.23,4.01	0.008	2.22	1.15,4.27	0.017
SUVmax> 12.7 g/mL	2.10	1.16,3.81	0.014	2.54	1.26,5.09	0.009
pT stage
pT0	Ref			Ref
pT1	0.30	0.06,1.45	0.135	0.59	0.11,3.04	0.532
pT2	1.32	0.49,3.57	0.577	1.55	0.56,4.28	0.393
pT3	2.78	1.18,6.55	0.019	3.31	1.37,8.00	0.008
pT4	11.93	2.25,63.29	0.004	7.24	1.34,39.22	0.022
Resection margins
R0	Ref
R+	2.47	1.04,5.89	0.041	2.09	0.77,5.68	0.147
Adenocarcinoma
Active smoking	2.34	1.04–5.28	0.039	2.54	1.05–6.14	0.039
SUVmax> 12.7 g/mL	1.87	0.85–4.11	0.119	1.54	0.65–3.62	0.323
pN stage
pN0	Ref			Ref
pN1	5.76	2.06–16.09	< 0.001	4.04	1.29–12.58	0.016
pN2	5.24	1.78–15.49	0.003	3.88	1.25–12.02	0.019
pN3	9.31	1.82–47.49	0.007	8.67	1.50–50.07	0.016
Resection margins
R0	Ref
R+	4.37	1.44–13.25	0.009	2.78	0.78–9.94	0.115
Squamous cell cancer
cT stage
cT1–2	Ref			Ref
cT3–4	2.74	0.92–8.10	0.069	0.96	0.19–4.78	0.961
SUVmax> 12.7 g/mL	1.82	0.76–4.36	0.176	5.06	1.44–17.71	0.011
pT stage
pT0	Ref			Ref
pT1	0.84	0.16–4.33	0.833	1.23	0.21–7.17	0.816
pT2	1.95	0.56–6.76	0.290	5.67	1.34–24.01	0.018
pT3	5.97	1.95–18.29	0.002	5.05	1.10–23.16	0.037
pT4	11.75	1.17–118.29	0.037	10.67	0.93–122.39	0.057
pN stage
pN0	Ref			Ref
pN1	0.22	0.03–1.67	0.144	0.09	0.01–0.92	0.042
pN2	4.51	1.42–14.31	0.010	4.71	1.00–22.14	0.049
pN3	4.39	0.95–20.32	0.058	6.72	0.90–49.88	0.062

HR Hazard ratio, 95%CI 95% confidence intervals, Ref Reference category, SUV_max Maximal standardized uptake value

ISSN: 1471-2342