Table 11 Complexity of 1-dimensional atrophy measurements and outcome associations
| Â | No. | Methodological complexity: | Outcome associations: |
|---|---|---|---|
LVB Width: | Â | Â | Â |
Current investigation | 177 | S-C | age, ICH, CSF volume |
Gonzalez, 1978 [2] | 100 | M-C (plus frontal horn width) | atrophy (subjective) |
LVB ÷ IC Width: |  |  |  |
Current investigation | 177 | S-C | age, CSF ÷ brain volume, CSF ÷ IC volume, ICH, dementia, anemia |
Earnest, 1979 [3] | 59 | S-C | age |
Gado, 1983 [4] | 24 | S-C | none |
Steiner, 1985 [5] | 148 | S-C | age |
Sulcal Width: | Â | Â | Â |
Current investigation | 177 | S-C | age, CSF volume, brain volume, CSF ÷ brain volume, CSF ÷ IC volume, ICH, dementia, cardiac history |
Ford, 1981 [7] | 59 | M-C (largest sulcus) | none |
Pirttila, 1992 [9] | 416 | M-C (subjective visual widening) | age, # medications, DM, HTN, CVA |
Pasquier, 1996 [10] | 50 | M-C (13 areas; subjective widening) | none |
Earnest, 1979 [3] | 59 | M-C (sum of 4-largest sulci) | age |
Gyldensted, 1977 [6] | 100 | M-C (largest width) | age |
Coyle, 2006 [11] | 35 | S-S (mean width) | none |
Kochunov, 2008 [12] | 31 | S-S (3-D mean span) | age |
Gonzalez, 1978 [2] | 100 | M-C (sum 4 largest on highest 3 cuts) | atrophy (subjective) |
Kohlmeyer, 1983 [8] | 150 | M-C (sum of widest for frontal, temporal, parietal lobes) | age |
Composite Atrophy: | Â | Â | Â |
Current investigation | 177 | S-C (see LVB Width & Sulcal Width, above) | brain volume, CSF volume, CSF ÷ brain volume, CSF ÷ IC volume, ICH, cardiac history, anti-thrombotic agent use |
Fox, 1975 [27] | 35 | M-C (sum LVB + frontal horn width; sum 4 largest sulci, highest 2 cuts) | atrophy (subjective) |
Gonzalez, 1978 [2] | 100 | M-C (see above) | atrophy (subjective) |