Table 1 MDR2 mouse characteristics
Mouse strain (n) | Time to HCC development (Months) | Histology | Maximum tumor size (mm) |
|---|---|---|---|
FVB (10) | N/A | Normal hepatic histology | N/A |
MDR2−/+ (10) | N/A | Normal hepatic histology | N/A |
MDR2−/− (10) | 9-12 M | Background liver: Moderate hepatic fibrosis. | 12 M – 7 ± 1 |
Tumor: Large cells with abundant eosinophilic cytoplasm and prominent central nuclei arranged in a trabecular pattern. Some tumor cells showed evidence of steatosis. | 15 M – 15 ± 1 | ||
18 M – 14 ± 2 |