Figure 3

The gradient in change of ADC across the tumor border on preoperative DWI for brain metastases, called the ATC (see Methods ) was strongly predictive of the cellularity, as shown in the scatterplot above. Cellularity was assessed in a semi-automated fashion using ImageJ software from five different high power fields and ATC measured as shown in Figure 1. The line shows a simple linear regression model which was highly significant (ATC = 0.007* mean cellularity + 0.07, ANOVA F = 9.84, p < 0.001).