Skip to main content

Table 6 Classification result for NC-AD, NC-MCI, and MCI-AD for the difference between the bl and month 12 makers 6(a) is the not adjusted case, 6(b) is adjusted for bl whole brain volume and 6(c) is adjusted for baseline hippocampus volume

From: Brain region’s relative proximity as marker for Alzheimer’s disease based on structural MRI

(a) Delta values, not adjusted
  NC-AD AUC p −value NC-MCI AUC p −value MCI-AD AUC p −value
HP/ICV 0.579 0.068 0.567 0.030 0.526 0.030
WB/ICV 0.600 0.020 0.588 0.004 0.588 0.004
Surface all 0.664 <0.001 0.643 <0.001 0.719 <0.001
Surface func 0.729 <0.001 0.732 <0.001 0.736 <0.001
Surface potato 0.716 <0.001 0.717 <0.001 0.718 <0.001
Procrustes all 0.630 <0.001 0.591 0.002 0.672 <0.001
Procrustes func 0.636 <0.001 0.612 <0.001 0.676 <0.001
Procrustes potato 0.695 <0.001 0.626 <0.001 0.681 <0.001
(b) Whole brain, bl. volume adjusted
  NC-AD AUC p −value NC-MCI AUC p −value MCI-AD AUC p −value
Surface all 0.629 0.003 0.630 <0.001 0.725 <0.001
Surface func 0.657 0.000 0.704 <0.001 0.739 <0.001
Surface potato 0.645 0.001 0.681 <0.001 0.707 <0.001
Procrustes all 0.605 0.004 0.575 0.011 0.655 <0.001
Procrustes func 0.593 0.011 0.586 0.003 0.647 <0.001
Procrustes potato 0.640 0.000 0.600 0.001 0.657 <0.001
(c) Hippocampus volume, bl. volume adjusted
  NC-AD AUC p −value NC-MCI AUC p −value MCI-AD AUC p −value
Surface all 0.591 0.034 0.597 0.002 0.712 <0.001
Surface func 0.575 0.082 0.649 <0.001 0.704 <0.001
Surface potato 0.582 0.056 0.630 <0.001 0.681 <0.001
Procrustes all 0.580 0.028 0.564 0.028 0.659 <0.001
Procrustes func 0.583 0.022 0.573 0.013 0.657 <0.001
Procrustes potato 0.615 0.002 0.577 0.008 0.664 <0.001
  1. Our markers was still able to significantly discriminate between the three groups. Our surface connectivity markers for the two subgroups functional and potato performed the best.