Brain region’s relative proximity as marker for Alzheimer’s disease based on structural MRI

BMC Medical Imaging

Table 6 Classification result for NC-AD, NC-MCI, and MCI-AD for the difference between the bl and month 12 makers 6(a) is the not adjusted case, 6(b) is adjusted for bl whole brain volume and 6(c) is adjusted for baseline hippocampus volume

(a) Delta values, not adjusted
	NC-AD AUC	p −value	NC-MCI AUC	p −value	MCI-AD AUC	p −value
HP/ICV	0.579	0.068	0.567	0.030	0.526	0.030
WB/ICV	0.600	0.020	0.588	0.004	0.588	0.004
Surface all	0.664	<0.001	0.643	<0.001	0.719	<0.001
Surface func	0.729	<0.001	0.732	<0.001	0.736	<0.001
Surface potato	0.716	<0.001	0.717	<0.001	0.718	<0.001
Procrustes all	0.630	<0.001	0.591	0.002	0.672	<0.001
Procrustes func	0.636	<0.001	0.612	<0.001	0.676	<0.001
Procrustes potato	0.695	<0.001	0.626	<0.001	0.681	<0.001
(b) Whole brain, bl. volume adjusted
	NC-AD AUC	p −value	NC-MCI AUC	p −value	MCI-AD AUC	p −value
Surface all	0.629	0.003	0.630	<0.001	0.725	<0.001
Surface func	0.657	0.000	0.704	<0.001	0.739	<0.001
Surface potato	0.645	0.001	0.681	<0.001	0.707	<0.001
Procrustes all	0.605	0.004	0.575	0.011	0.655	<0.001
Procrustes func	0.593	0.011	0.586	0.003	0.647	<0.001
Procrustes potato	0.640	0.000	0.600	0.001	0.657	<0.001
(c) Hippocampus volume, bl. volume adjusted
	NC-AD AUC	p −value	NC-MCI AUC	p −value	MCI-AD AUC	p −value
Surface all	0.591	0.034	0.597	0.002	0.712	<0.001
Surface func	0.575	0.082	0.649	<0.001	0.704	<0.001
Surface potato	0.582	0.056	0.630	<0.001	0.681	<0.001
Procrustes all	0.580	0.028	0.564	0.028	0.659	<0.001
Procrustes func	0.583	0.022	0.573	0.013	0.657	<0.001
Procrustes potato	0.615	0.002	0.577	0.008	0.664	<0.001

Our markers was still able to significantly discriminate between the three groups. Our surface connectivity markers for the two subgroups functional and potato performed the best.

ISSN: 1471-2342