The use of high-frequency ultrasound imaging and biofluorescence for in vivoevaluation of gene therapy vectors

BMC Medical Imaging

Table 1 Pearson correlation coefficients of xenograft tumour volumes using different ellipsoid formulae and measured using mechanical callipers, HF-US or mass

		π/6 × L × W × H	0.5 × L × W × H	HF-US	Mass (g)
0.5 × L × W²	R ²	0.7867	0.7867	0.8576	0.7843
	95% CI	0.5421-0.9761	0.5421-0.9761	0.7110-0.9827	0.4811-0.9792
	p	0.0014	0.0014	0.0001	0.0034
π/6 × L × W²	R ²	0.7867	0.7867	0.8576	0.7843
	95% CI	0.5421-0.9761	0.5421-0.9761	0.7110-0.9827	0.4811-0.9792
	p	0.0014	0.0014	0.0001	0.0034
π/6 × (L × W)^3/2	R ²	0.8325	0.8325	0.8636	0.8492
	95% CI	0.6300-0.9817	0.6300-0.9817	0.7223-0.9835	0.6184-0.9860
	p	0.0006	0.0006	0.0001	0.0011
HF-US	R ²	0.7993	0.7993		0.8470
	95% CI	0.6342-0.9724	0.6342-0.9724		0.6135-0.9857
	p	0.0002	0.0002		0.0012
Mass (g)	R ²	0.9254	0.9254
	95% CI	0.7580-0.9946	0.7580-0.9946
	p	0.0005	0.0005

Three different formulae for generating in vivo tumour volumes using callipers are shown to the left and two different formulae for ex vivo tumour volumes using callipers on top. Each have been subject to pairwise comparison to determine the different correlation coefficients.

ISSN: 1471-2342