Figure 1

Longitudinal growth of xenograft tumours using mechanical callipers and HF-US. Growth of xenografts generated from each line using mechanical Vernier callipers on the external surface of the animal (in vivo calliper volume – solid lines) and using 3D high-frequency ultrasound scans and calculating volumes by drawing regions of interest on each frame (dotted lines). Mean volume +/- standard deviation of each group is shown (n = 5 for calliper measurements and 6 for HF-US) * denotes that mice were culled in this group after this point due to large tumour volumes (n = 2 from day 28).