Novel computed tomographic chest metrics to detect pulmonary hypertension

BMC Medical Imaging

Table 6 Multiple logistic regression to control for potential confounders

	P	OR	AUC	Sensitivity (%)	Specificity (%)
Main PA diameter ≥29 mm	0.0196	4.8	0.93	77.4	89.6
Left PA diameter ≥24 mm	0.2160	2.6	0.92	77.4	87.5
Right PA diameter ≥25 mm	0.4461	1.9	0.91	73.6	93.8
RDPA diameter ≥19 mm	0.0059	7.0	0.93	83.0	85.4
True RDPA diameter ≥16 mm	0.0487	4.1	0.92	83.0	87.5
True LDPA diameter ≥21 mm	0.0075	15.5	0.93	79.2	91.7
RV free wall ≥6 mm	0.0303	30.5	0.95	81.0	91.9
RV lumen ≥30 mm	0.0915	5.8	0.95	92.9	73.0
LV free wall ≥15 mm	0.1607	5.2	0.95	85.7	83.8
LV lumen ≥57 mm	0.3945	3.0	0.94	76.2	88.9
Hilar diameter ≥124 mm	0.2968	2.2	0.92	81.1	75.0
RV wall/LV wall ratio ≥0.32	0.0141	8.8	0.96	78.6	83.8
RV lumen/LV lumen ratio ≥1.28	0.0196	28.8	0.95	85.7	86.1
L apical artery/bronchus ratio ≥1.75	0.2851	3.5	0.92	75.5	87.5
Hilar/thoracic ratio ≥0.52	0.0757	3.7	0.92	75.5	87.5
Main PA/AA ratio ≥0.84	0.0208	6.0	0.93	73.6	91.7
Main PA/DA ratio ≥1.29	0.0269	5.7	0.93	77.4	89.6
IV septum bowing into LV (yes or no)	0.1053	11.6	0.95	81.0	89.2
Main PA/AA ratio >1	0.0085	9.1	0.93	86.8	79.2

Regression of the outcome variable (PH vs. no-PH) to the predictors:
ULN for each hypothesized predictor of PH, age, sex, ascending aorta diameter (AA), BSA, thoracic diameter (TD), and pulmonary wedge pressure (PWP) >15 mmHg.
Note: one logistic regression model was created for each hypothesized predictor of PAH. For example, the analysis in the first row above included the predictors: Main PA diameter ≥29, age, sex, AA, BSA, TD, and PWP >15. See table 1 for definitions of radiographic metrics.

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