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Table 1 Study characteristics of RCTs included in the meta-analysis

From: Patient Discomfort Associated with the Use of Intra-arterial Iodinated Contrast Media: A Meta-Analysis of Comparative Randomized Controlled Trials

Study Injection Site and/or Procedure Treatment group Number of patients in comfort analysis Number (%) of Females Age (Mean [SD]) Weight (Mean [SD])
Andersen et al[28] Left ventricle & selective coronary artery injections (left and right) Iodixanol 36 9 (25.0) 54 81
   Ioxaglate 38 13 (34.2) 56 77
Fischbach et al[29] Celiac trunk/spiral CT angiography of abdominal aorta Iodixanol 40 10 (25.0) 65.7 ± 11.4 77.1 ± 14.7
   Ioversol 38 6 (15.8) 61 ± 11.1 78 ± 11.5
Flinck et al[30] Cardioangiography Iodixanol 44 8 (18.2) 62.5 80
   Ioxaglate 44 8 (18.2) 62.5 80
Hekster et al[31] Multiple carotid and vertebral arteries/IA cerebral DSA Iodixanol 40 16 (40.0) 61 74
   Iohexol 39 14 (35.9) 57 71
Hill et al[32] Coronary and left ventricular angiography Iodixanol 101 20 (19.8) 61 ± 10.0 unknown
   Iohexol 99 12 (12.1) 59 ± 11.0 unknown
Justesen et al[15] Femoral arteriography Iodixanol 1225 343 (28.0) 65.6 ± 11.5 71.8 ± 12.5
   Iopromide 1227 339 (27.6) 65 ± 11.3 71.7 ± 12.9
Kendall et al[24] IA cerebral digital subtraction angiography Iodixanol 44 22 (50.0) 49.7 ± 11.0 70.2 ± 13.5
   Iohexol 42 24 (57.1) 45.7 ± 13.3 70.9 ± 13.4
Klow et al[33] Left ventriculography, selective coronary arteriography, and thoracic aortography Iodixanol 35 unknown 54 ± 9.0 80 ± 10.0
   Iohexol 37 unknown 55 ± 9.0 81 ± 13.0
Manke et al[22] Femoral arteriography Iodixanol 163 22 (13.5) 63.6 ± 11.2 74.4 ± 12.9
   Iomeprol 165 36 (21.8) 65.2 ± 11.6 74.8 ± 12.6
Manninen et al[34] IA Iodixanol 50 24 (48.0) 69 unknown
   Iohexol 50 24 (48.0) 69 unknown
Palmers et al[25] Cerebral arteriography Iodixanol 40 14 (35.0) 54.9 69.7
   Ioxaglate 40 18 (45.0) 48.9 73.9
Poirier et al [18] Cerebral angiography Iodixanol 51 unknown unknown unknown
   Iohexol 48 unknown unknown unknown
Pugh et al [19] Femoral arteriography Iodixanol 48 12 (25.0) 65 ± 8.9 74.3 ± 14.7
   Iopromide 47 13 (27.7) 68 ± 10.4 73.9 ± 12.1
Roriz et al [26] Left ventricular cardioangiography Iodixanol 54 13 (24.1) 58 ± 11.0 75 ± 9.0
   Ioxaglate 53 13 (24.5) 57 ± 10.0 75 ± 12.0
Rosenblum et al [27] Peripheral and aortic angiography Iodixanol 19 13 (68.4) 64 ± 11.0 76 ± 18.0
   Ioxaglate 25 9 (36.0) 68 ± 9.0 76 ± 16.0
Siegel et al [21] Aortography, renal/visceral angiography Iodixanol 29 11 (37.9) 51 ± 19.0 76 ± 17.0
   Ioxaglate 25 9 (36.0) 52 ± 15.0 74 ± 18.0
Singh et al [35] Abdominal aorta/Abdominal angiography Iodixanol 39 10 (25.6) 59.1 70.3
   Iohexol 20 8 (40.0) 66.1 70.3
Sutton et al [16] Cardiac catheterization/femoral arteriography Iodixanol 468 173 (37.0) 60.2 ± 10.0 76.5 ± 14.7
   Ioxaglate, Iopamidol 1128 367 (32.5) 60.3 95.1
Sutton et al [17] Cardiac catheterization/coronary angiography Iodixanol 665 222 (33.4) 60.7 ± 10.2 78 ± 14.0
   Iopamidol, Iomeprol 1443 505 (35.0) 60.4 78.5
Thorstensen et al [23] Femoral arteriography Iodixanol 73 31 (42.5) 67.6 ± 12.5 68 ± 12.9
   Iohexol 74 33 (44.6) 67.8 ± 11.3 70.2 ± 14.5
Tveit et al [36] Left ventricular cardioangiography Iodixanol 53 9 (17.0) 58 76.9
   Ioxaglate 49 12 (24.5) 58 77.9
Verow et al [20] Aorta/Femoral arteriography Iodixanol 68 unknown unknown unknown
   Iopamidol 65 unknown unknown unknown
Combined papers   Iodixanol 3385 982 (29) 62.5 74.5*
   All LOCMs Combined 4796 1463 (30.5) 61.7 80.2
  1. *Indicates significant difference between groups (p < 0.05)