Table 1 Study characteristics of RCTs included in the meta-analysis
Study | Injection Site and/or Procedure | Treatment group | Number of patients in comfort analysis | Number (%) of Females | Age (Mean [SD]) | Weight (Mean [SD]) |
|---|---|---|---|---|---|---|
Andersen et al[28] | Left ventricle & selective coronary artery injections (left and right) | Iodixanol | 36 | 9 (25.0) | 54 | 81 |
Ioxaglate | 38 | 13 (34.2) | 56 | 77 | ||
Fischbach et al[29] | Celiac trunk/spiral CT angiography of abdominal aorta | Iodixanol | 40 | 10 (25.0) | 65.7 ± 11.4 | 77.1 ± 14.7 |
Ioversol | 38 | 6 (15.8) | 61 ± 11.1 | 78 ± 11.5 | ||
Flinck et al[30] | Cardioangiography | Iodixanol | 44 | 8 (18.2) | 62.5 | 80 |
Ioxaglate | 44 | 8 (18.2) | 62.5 | 80 | ||
Hekster et al[31] | Multiple carotid and vertebral arteries/IA cerebral DSA | Iodixanol | 40 | 16 (40.0) | 61 | 74 |
Iohexol | 39 | 14 (35.9) | 57 | 71 | ||
Hill et al[32] | Coronary and left ventricular angiography | Iodixanol | 101 | 20 (19.8) | 61 ± 10.0 | unknown |
Iohexol | 99 | 12 (12.1) | 59 ± 11.0 | unknown | ||
Justesen et al[15] | Femoral arteriography | Iodixanol | 1225 | 343 (28.0) | 65.6 ± 11.5 | 71.8 ± 12.5 |
Iopromide | 1227 | 339 (27.6) | 65 ± 11.3 | 71.7 ± 12.9 | ||
Kendall et al[24] | IA cerebral digital subtraction angiography | Iodixanol | 44 | 22 (50.0) | 49.7 ± 11.0 | 70.2 ± 13.5 |
Iohexol | 42 | 24 (57.1) | 45.7 ± 13.3 | 70.9 ± 13.4 | ||
Klow et al[33] | Left ventriculography, selective coronary arteriography, and thoracic aortography | Iodixanol | 35 | unknown | 54 ± 9.0 | 80 ± 10.0 |
Iohexol | 37 | unknown | 55 ± 9.0 | 81 ± 13.0 | ||
Manke et al[22] | Femoral arteriography | Iodixanol | 163 | 22 (13.5) | 63.6 ± 11.2 | 74.4 ± 12.9 |
Iomeprol | 165 | 36 (21.8) | 65.2 ± 11.6 | 74.8 ± 12.6 | ||
Manninen et al[34] | IA | Iodixanol | 50 | 24 (48.0) | 69 | unknown |
Iohexol | 50 | 24 (48.0) | 69 | unknown | ||
Palmers et al[25] | Cerebral arteriography | Iodixanol | 40 | 14 (35.0) | 54.9 | 69.7 |
Ioxaglate | 40 | 18 (45.0) | 48.9 | 73.9 | ||
Poirier et al [18] | Cerebral angiography | Iodixanol | 51 | unknown | unknown | unknown |
Iohexol | 48 | unknown | unknown | unknown | ||
Pugh et al [19] | Femoral arteriography | Iodixanol | 48 | 12 (25.0) | 65 ± 8.9 | 74.3 ± 14.7 |
Iopromide | 47 | 13 (27.7) | 68 ± 10.4 | 73.9 ± 12.1 | ||
Roriz et al [26] | Left ventricular cardioangiography | Iodixanol | 54 | 13 (24.1) | 58 ± 11.0 | 75 ± 9.0 |
Ioxaglate | 53 | 13 (24.5) | 57 ± 10.0 | 75 ± 12.0 | ||
Rosenblum et al [27] | Peripheral and aortic angiography | Iodixanol | 19 | 13 (68.4) | 64 ± 11.0 | 76 ± 18.0 |
Ioxaglate | 25 | 9 (36.0) | 68 ± 9.0 | 76 ± 16.0 | ||
Siegel et al [21] | Aortography, renal/visceral angiography | Iodixanol | 29 | 11 (37.9) | 51 ± 19.0 | 76 ± 17.0 |
Ioxaglate | 25 | 9 (36.0) | 52 ± 15.0 | 74 ± 18.0 | ||
Singh et al [35] | Abdominal aorta/Abdominal angiography | Iodixanol | 39 | 10 (25.6) | 59.1 | 70.3 |
Iohexol | 20 | 8 (40.0) | 66.1 | 70.3 | ||
Sutton et al [16] | Cardiac catheterization/femoral arteriography | Iodixanol | 468 | 173 (37.0) | 60.2 ± 10.0 | 76.5 ± 14.7 |
Ioxaglate, Iopamidol | 1128 | 367 (32.5) | 60.3 | 95.1 | ||
Sutton et al [17] | Cardiac catheterization/coronary angiography | Iodixanol | 665 | 222 (33.4) | 60.7 ± 10.2 | 78 ± 14.0 |
Iopamidol, Iomeprol | 1443 | 505 (35.0) | 60.4 | 78.5 | ||
Thorstensen et al [23] | Femoral arteriography | Iodixanol | 73 | 31 (42.5) | 67.6 ± 12.5 | 68 ± 12.9 |
Iohexol | 74 | 33 (44.6) | 67.8 ± 11.3 | 70.2 ± 14.5 | ||
Tveit et al [36] | Left ventricular cardioangiography | Iodixanol | 53 | 9 (17.0) | 58 | 76.9 |
Ioxaglate | 49 | 12 (24.5) | 58 | 77.9 | ||
Verow et al [20] | Aorta/Femoral arteriography | Iodixanol | 68 | unknown | unknown | unknown |
Iopamidol | 65 | unknown | unknown | unknown | ||
Combined papers | Iodixanol | 3385 | 982 (29) | 62.5 | 74.5* | |
All LOCMs Combined | 4796 | 1463 (30.5) | 61.7 | 80.2 |