Safely reducing unnecessary benign breast biopsies by applying non-mass and DWI directional variance filters to ADC thresholding

Table 3 Dataset and ADC statistics

	100% Sensitivity Method	LM Method		ADC Thresholding only	ADC Thresholding with filters
Primary author of study	Partridge, et al	Rahbar, et al	Clauser, et al	Current Study
Number Institutions	1	10	7	1	1
Data sets analyzed	1	1	7	1	1
Benign lesions	52	39	282	31	31
Malignant lesions	31	28	414	38	38
% Non-mass lesions	41%	42%	26%	26%	26%
Prevalence	0.373	0.346	0.595	0.551	0.551
ADC_MaxMalig	1.81	1.53		1.89	1.53
Potentially avoidable unnecessary biopsies at ADC_MaxMalig	17(33%)	14(36%)		3(10%)	13(42%)
LR- (ADC cutoff 1.5)			.10	.27	.06

“ADC”—apparent diffusion coefficient, “ADC_MaxMalig”—maximum ADC value of malignant lesions, “LR-”—negative likelihood ratio, “Prevalence”—number of malignant lesions over total number of lesions

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