Dose gradient | Radiomics feature | Total |
|---|
FirstOrder | GLCM | GLDM | GLRLM | GLSZM | NGTDM |
|---|
0–5 Gy | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
5–10 Gy | 2 | 0 | 0 | 0 | 0 | 0 | 2 |
10–15 Gy | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
15–20 Gy | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
20–30 Gy | 18 | 18 | 8 | 10 | 10 | 2 | 66 |
30–40 Gy | 11 | 12 | 7 | 8 | 10 | 2 | 55 |
40–50 Gy | 7 | 17 | 2 | 3 | 3 | 2 | 34 |
- Among these features, the radiomics features with the most changes before and after RT under the dose gradients 0–5 Gy, 5–10 Gy, 10–15 Gy, 20–30 Gy, 30–40 Gy, and 40–50 Gy were GLSZM-GreyLevelNonUniformity (9.13%), FirstOrder-TotalEnergy (23.95%), GLSZM-LargeAreaHighGrayLevelEmphasis (−7.74%), FirstOrder-Skewness (−43.13%), GLSZM-SizeZoneNonUniformity (32.15%), and NGTDM-Complexity (49.21%), respectively
- There were 20 general features under dose gradients of 20–30 Gy, 30–40 Gy, and 40–50 Gy, which mainly included FirstOrder (3), GLCM (11), GLDM (1), GLSZM (2), GLRLM (2), and NGTDM (1). Among these, the changes in the feature GLSZM-GreyLevelNonUniformityNomalized under the dose gradients 20–30 Gy and 30–40 Gy showed a downwards trend with an increase in the dose, whereas the other features decreased at first and then increased in a dose-dependent manner (Fig. 4)
